内科学第2講座

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和歌山県立医科大学第二内科は、内科2講座2教授制となった昭和29年に開講しました。楠井賢造先生、矢高勲先生、西岡新吾先生、一瀬雅夫先生の先代4教授が築き上げられた当講座を、平成28年7月より引き継がせていただいております。当講座は300人以上の医師を輩出し、和歌山県における消化器内科領域の教育?研究?診療の中心的存在であり、さらに地域医療を担う医師を育成する教育機関としての重要な役割を担っております。

当講座は、消化管?肝胆膵全領域にわたり最先端診療?研究を行う専門領域のバランスのとれた教室です。私は主に胆膵疾患に対する最先端内視鏡?超音波技術を実践し、新しい診療技術の研究開発を行ってきました。前任の一瀬教授はHelicobacter pylori感染と胃癌の研究において、世界的な研究実績があります。炎症性腸疾患の診療では、多数の治験を実施し、最先端診療を提供してきております。消化管内視鏡治療では内視鏡的粘膜下層剥離術（ESD）件数が全国でも有数であり、最も難易度が高いと言われている大腸腫瘍に対するESDを実施できる医師が4名在籍しております。肝癌に対するラジオ波焼灼術は県内全域?泉南地域の治療の中心的存在であり、各地域より肝癌の患者さんが紹介されてきており、全国でもトップ10に入る実績があります。

消化管?肝胆膵の全臓器に関する、基礎から臨床研究まで、スクリーニングから最先端治療まで全ての領域を網羅することを教室の基本方針としております。また、消化器内科は急性期疾患が多く、「フットワークの軽い診療姿勢」が重要です。和歌山県内で発症した消化器疾患をできるだけ早急に受け入れ、高度かつ最善の医療を提供できるよう努めて行きたいと考えております。県の医療の中心的役割を果たしているという自覚を持ち、消化器疾患患者の最後の砦として、他施設からの患者の受け入れを積極的に行っております。

内視鏡および超音波等を用いた診断?治療では、最先端診療を実践すると同時に新規技術の研究開発を行っております。一方で、和歌山県は人口移動の少ない県であることから、地域医療を活用した和歌山県全体に及ぶ大規模な臨床研究を積極的に実施し、県民の健康増進に努めております。私の就任後、「きのくにプロジェクト」と称した膵癌早期発見の地域医療連携システムを構築し、和歌山県における膵癌患者の予後改善に努めております。

最後に、全員が一丸となって、和歌山県における消化器疾患の予後向上をめざし、最先端診療?研究を世界に向けて発信し続けていく所存です。

教授　北野　雅之

教育概要

当講座の基本的教育方針として、医局員全員が基本的消化器診療技術を修得し、大学あるいは関連病院に来院する、いかなる消化器疾患患者にも対応できるよう教育しております。また、早期に内科専門医、消化器関連専門医（消化器病学会、消化器内視鏡学会、肝臓学会、超音波医学会）を取得することを目標しております。

当講座の特徴的な教育方針として、消化管?肝?胆膵の全領域の専門医が一名ずつ構成されているグループで診療活動を行い、研修医がそのグループの一員として働くことにより、消化器全領域を偏りなく研修できることが挙げられます。また、内視鏡等の検査の際には、常時指導医とともにペアで手技を実施することとなっており、指導面でも重厚な体制で臨んでいます。

消化器関連専門医取得後は、それぞれの目的に応じた「懐の広い」指導体制を整えております。全ての基本的な内視鏡技術、超音波技術を早期に修得できるよう、それぞれの研修カリキュラムを組んでおります。また、大学で研究活動を積極的に行い、その研究成果を世界へ向けて発信する研究者、最先端診療を実践し県内外から診療依頼を受け、国際学会で内視鏡ライブデモンストレーションを行うエキスパートを多く育成することも教室の重要な役割と考えております。さらに、地域中核病院へ出向し、消化器疾患診療を中心として地域医療を守ることも重要な貢献となります。

初期研修について

  1. 概要
    一般的な内科疾患への診療能力を身に付ける。同時に、消化器系専門診療の基礎を学び、消化器疾患への適切な初期対応、適切な専門医への相談ができるようになる。
  2. 内容
    診療グループの一員として、指導医のもとで、病棟を中心に消化器疾患全般を診療する。シュミレーターによるトレーニングの後に、内視鏡?超音波の検査?治療に積極的に参加する。
  3. 体制
    卒後15−20年目の指導医1名、卒後10年目程度の中間指導医が、診療グループを組んで、指導する。3カ月を基本とし、受け入れ可能人数 10名以内とする。

専門研修について

年次
3 4 5 6 7 8 9 10 11以降
大学病院            
院内救急部
（3ヵ月）		                
内科研修 内科専門医          
消化器専門研修 消化器系専門医    
  1. 概要
    新しい専門医制度に対応している。　消化器研修に重点を置くことで、最短卒後６年後に、消化器系専門医を取得することができる。
  2. 研修内容
    診療グループの一員として、主治医の指導のもと、消化器疾患を偏りなく診療する。内視鏡?超音波検査を含めた基本的手技を修得する。習熟度と希望に応じ、専門的な高度技術である内視鏡的逆行性胆管膵管造影(ERCP)、内視鏡的粘膜下層切開剥離術(ESD)、経皮的ラジオ波焼灼術(RFA)を専門研修中に開始することも可能である。また、研究活動を通じて、診療上の疑問を科学的に解決する方法を身に付ける。
  3. 教育体制
    病棟?外来での診療、内視鏡?超音波検査、当直などあらゆる業務において、常に指導医がバックアップするのが特徴である。内科学会指導医12名、消化器病学会指導医５名、消化器内視鏡学会指導医9名などが指導にあたる。
  4. 専門研修協力病院
    和歌山ろうさい病院、日本赤十字社和歌山医療センター、りんくう総合医療センター、橋本市民病院、新宮市立医療センター、南和歌山医療センター
    日高総合病院、済生会有田病院、有田市立病院、済生会和歌山病院、国保野上厚生総合病院
    近畿大学、昭和大学、三井記念病院、東京大学
  5. 専門医取得
    内科専門医、消化器病専門医、消化器内視鏡専門医、肝臓専門医、超音波専門医、がん治療認定医、がん検診認定医、胃腸科専門医、カプセル内視鏡認定医
  6. 連絡先
    見学も随時受け付けています。
    ninai@wakayama-med.ac.jp

研究概要

当内科の専門分野である消化器疾患を中心に、特に悪性腫瘍を対象に基礎的及び臨床的研究を行っています。

当科では、症例一例ごとにベストの医療を模索する中で、スタッフが、対象疾患に対する自らの診療のなかで、直面する問題点を辛抱強く追及してゆく過程で自然発生するテーマを対象にして研究を行っています、研究結果が臨床医としての能力向上に何らかの形で役立ち、最終的には医療に還元出来るものとなることを目標としています。

基礎的研究では、臨床教室のみで実施せず、基礎教授との共同研究により高次元の研究を実施しています。特に臨床応用できる基礎的研究（トランスレーショナルリサーチ）に力を入れています。

臨床的研究では、画像診断、内視鏡治療、化学療法等に関する新しい技術を研究開発すると同時に、多施設共同研究を通じて、ガイドラインに引用されるような治療上重要なエビデンスを得る研究を実践しています。

以下に教室の研究テーマを示します。

  1. 消化管、胆道および膵疾患の内視鏡下治療の新規技術開発検討。
  2. 消化器疾患診療に対する画像診断(内視鏡?超音波)の技術革新と診断精度向上に関する検討。
  3. 肝腫瘍性病変を対象にした経皮局所治療に関する検討。
  4. 地域医療連携を活用した膵癌早期診断システムの構築
  5. 消化器癌スクリーニングの精度および効率向上に関する検討。
  6. 消化器系慢性疾患、悪性疾患の臨床疫学的検討。
  7. 上部消化管内腔環境規定要因としての胃酸、ペプシン分泌機構に関する検討。
  8. 各種肝炎ウイルスの感染、増殖動態の解明およびその制御に関する検討。
  9. 消化器癌の chemoprevention に関する検討。
  10. 再生医学を視野に入れた消化器実質組織の増殖、分化、形態形成、apoptosis 制御機構の検討。
  11. 消化器癌の増殖、分化、転移の分子機構の解明および臨床応用に関する検討。
  12. 消化器領域の慢性炎症性疾患の自然史、基本病態およびその制御に関する検討。
  13. 消化管における創傷治癒調節機構および quality of ulcer healing 向上に関する検討。
  14. 消化器の老化に伴う病態に関する検討。
  15. 消化器内科領域の卒前、卒後医学教育法に関する検討。
  16. 消化器癌化学療法の効果に関する検討。

現在、大学院生が進めている研究内容

  1. 消化器疾患に対する内視鏡?超音波を用いた新規診療技術の開発
  2. 消化器癌スクリーニング法の開発と精度、効率向上に関する研究
  3. 消化器疾患の予後向上を目指した地域医療連携システム構築に関する研究
  4. 消化器癌の増殖、分化、転移の分子機構の解明とバイオマーカーに関する研究
  5. 消化器における炎症性疾患の病態生理の解明と治療薬の開発
  1. Research and development of the techniques with endoscopy and ultrasonography for diagnosis and treatment of gastroenterological diseases
  2. Development of new methods for gastroenterological cancer screening and research to clarify their accuracy and efficiency
  3. Clinical epidemiological research to establish the regional systems for the prognostic improvement of gastroenterological diseases
  4. Research to clarify the molecular mechanisms of proliferation, differentiation and metastasis of gastroenterological cancer as well as their biomarkers.
  5. Research to clarify the pathophysiology of inflammatory diseases of digestive organs and development of their new therap

診療概要

診療内容（専門領域）、診療方針

第二内科の診療は、内科疾患、特に消化器（消化管、肝臓、胆膵）系疾患を専門分野として診療を行っています。すなわち、関連施設との連携により多数の症例が集まる肝癌、胃癌、大腸癌をはじめとする消化器悪性腫瘍を標的に、診療グループを１）上部消化管　２）下部消化管　３）肝臓　４）胆膵の4つに分けてグル-プで診療活動を行っています。

消化管および胆膵系悪性疾患に対しては内視鏡を中心にした診断法の精度、効率の向上に努めつつ、早期病変に対する内視鏡的粘膜下層剥離術（ESD）などの治療を積極的に行いながら、これらの手技の改良に努めています。

その他、消化器疾患診療に対するdynamic imageの導入、H.pylori除菌や肝炎ウイルスに対するインターフェロン療法などによる慢性炎症制御による当該領域の発癌制御、予後の改善、急性出血例に対する対応を含めたAcid peptic disorders の制御、炎症性腸疾患の治療、特に治療抵抗例に対する白血球除去療法はじめとする治療法の検討、肝癌に対する経皮的ラジオ波焼灼療法（RFA）などに力点をおいているのが特徴です。

さらに救急集中治療部へも教室員を派遣し、消化器系の救急重症疾患にも協力して対応できる様に努めています。

最近3年間の診療実績

以下の通り、外来、入院とも患者数は増加傾向にあります。

１）外来患者数の推移

月曜日から金曜日、各4診を用いて診療を行っています（新患診1名、再来3名）。

最近3年間の第二内科外来受診者の推移は以下の通りです。

  博狗体育平台_博狗体育在线-集团网站1年度 博狗体育平台_博狗体育在线-集团网站2年度 博狗体育平台_博狗体育在线-集团网站3年度
外来患者数 29715名 31043名 34646名
新患数 2008名 2282名 2169名

２）入院患者数の推移

現在、病床数は公称40床です。病棟は看護師長以下21名、診療医、指導医が診療を担当しています。毎週水曜日にチャートラウンド、毎週木曜日に回診、その他疾患ごとに専門グループによる検討会を加え、診療の充実に努めています。

疾患構成はおよそ肝臓疾患60％、消化管疾患30％、胆膵疾患10％程度です。悪性腫瘍での入院が約80％を占めています。その他は消化管出血、炎症性疾患（胆道系炎症＆結石?肝炎?膵炎、炎症性腸疾患）?C型肝炎ウィルスに対するインターフェロン療法などです。

初発、3cm、3個以内の肝細胞癌に対する経皮的ラジオ波焼灼療法（RFA）の5生率は72％です。消化管腫瘍性病変に対する内視鏡的切開剥離術（ESD）は、300例を超えています。

消化器系の検査件数は、腹部超音波検査年間約2000件で?外来約1400件?病棟約600件(診断および治療でそれぞれ約300件)?内視鏡検査(上部2000例、上部治療350例?上部超音波検査250例?下部1200例?下部治療200例?下部超音波検査50例)です。

最近3年間の入院患者数は以下の通りです。

  博狗体育平台_博狗体育在线-集团网站1年度 博狗体育平台_博狗体育在线-集团网站2年度 博狗体育平台_博狗体育在线-集团网站3年度
入院患者(年間延べ数) 15942名 16458名 16925名

スタッフ紹介（2023年4月現在）

役職 氏名 学会認定
教授 北野　雅之 内科学会認定医、指導医
消化器病学会専門医、指導医、財団評議員
消化器内視鏡学会専門医、指導医、社団評議員
超音波学会専門医、指導医、評議員、理事
胆道学会　指導医、評議員
膵臓学会　指導医、評議員、理事
臨床薬理学会　指導医、評議員
准教授 井口　幹崇 内科学会認定医、指導医
消化器病学会専門医、指導医、評議員
消化器内視鏡学会専門医、指導医、社団評議員
准教授 前北　隆雄 内科学会認定医、指導医
消化器病学会専門医、指導医、評議員
消化器内視鏡学会専門医、指導医、評議員
肝臓学会専門医、指導医
がん治療認定医
消化器がん検診学会認定医、総合認定医
消化管学会専門医
准教授 蘆田　玲子 内科学会認定医、総合内科専門医、指導医
消化器病学会専門医、指導医、学会評議員
消化器内視鏡学会専門医、指導医、社団評議員
超音波学会専門医、指導医、評議員
膵臓学会専門医、　指導医、評議員
消化器がん検診学会認定医、指導医
日本遺伝性腫瘍学会専門医、指導医
講師 井田　良幸 内科学会認定医、指導医
消化器病学会専門医、地方評議員
消化器内視鏡学会専門医
肝臓学会専門医、指導医、西部会評議員
講師 糸永　昌弘 内科学会認定医、総合内科専門医、指導医
消化器病学会専門医、指導医、地方評議員
消化器内視鏡学会専門医、指導医、地方評議員
講師 山下　泰伸 内科学会認定医、総合内科専門医、指導医
消化器病学会専門医、指導医、評議員
消化器内視鏡学会専門医、指導医、評議員
肝臓学会専門医、指導医
超音波医学会専門医
がん治療認定医
講師 田村　崇 内科学会認定医、総合内科専門医、指導医
消化器病学会専門医、指導医、地方評議員
消化器内視鏡学会専門医、指導医、地方評議員
肝臓学会専門医
助教 幡丸　景一 内科学会認定医、総合内科専門医
消化器病学会専門医
消化器内視鏡学会専門医、指導医
肝臓学会専門医
助教 清水　遼 内科学会認定医
消化器病学会専門医
肝臓学会専門医
助教 川路　祐輝 内科学会認定医
肝臓学会専門医
消化器病学会専門医
消化器内視鏡学会専門医
助教 前島　秀哉 内科学会認定医
肝臓学会専門医
助教 瀧　真也 内科学会認定医
消化器病学会専門医
消化器内視鏡学会専門医、地方評議員
肝臓学会専門医
助教 木下　淳 内科学会認定医
消化器病学会専門医
消化器内視鏡学会専門医
助教 桑島　史明 内科学会認定医
消化器病学会専門医
消化器内視鏡学会専門医
助教 髙尾　政輝 内科学会認定医
消化器病学会専門医
学内助教 加治　汐梨 内科学会専門医
学内助教 四至本　貴大 内科学会専門医
消化器病学会専門医
消化器内視鏡学会専門医
学内助教 鴻谷　浩武  
学内助教 田村　崇祥  
学内助教 谷口　侑大  
学内助教 深海　三恵  
学内助教 中谷　優  
学内助教 中畑　明耶  
学内助教 横山　英一郎  
学内助教 和田　梓  
学内助教 酒井　亮太  
学内助教 杉原　悠斗  
学内助教 髙橋　拓矢  
学内助教 山崎　博史  
学内助教 山口　敦弘  
学内助教 山田　晃佑  
学内助教 岡本　滋史  
学内助教 高橋　克典  
学内助教 坪田　悠佑  

文献

  1. Arizumi T, Ueshima K, Iwanishi M, Minami T, Chishina H, Kono M, Takita M, Kitai S, Inoue T, Yada N, Hagiwara S, Ida H, Minami Y, Sakurai T, Kitano M, Nishida N, Kudo M: Validation of a Modified Substaging System (Kinki Criteria) for Patients with Intermediate-Stage Hepatocellular Carcinoma. Oncology. 89 Suppl 2: 47-52, 2015
  2. Arizumi T, Ueshima K, Iwanishi M, Chishina H, Kono M, Takita M, Kitai S, Inoue T, Yada N, Hagiwara S, Ida H, Minami Y, Sakurai T, Nishida N, Kitano M, Kudo M*: Real-life clinical practice with Sorafenib in advanced hepatocellular carcinoma: A single-center experience second analysis. Dig Dis 33: 728-734, 2015
  3. Arizumi T, Ueshima K, Iwanishi M, Minami T, Chishina H, Kono M, Takita M, Kitai S, Inoue T, Yada N, Hagiwara S, Ida H, Minami Y, Sakurai T, Nishida N, Kitano M, Kudo M: Evaluation of ART Scores for Repeated Transarterial Chemoembolization in Japanese Patients with Hepatocellular Carcinoma. Oncology. 89 Suppl 2: 4-10, 2015
  4. Arizumi T, Ueshima K, Iwanishi M, Minami T, Chishina H, Kono M, Takita M, Kitai S, Inoue T, Yada N, Hagiwara S, Minami Y, Ida H, Sakurai T, Kitano M, Nishida N, Kudo M. Validation of Kinki Criteria, a Modified Substaging System, in Patients with Intermediate Stage Hepatocellular Carcinoma. Dig Dis. 34: 671-678, 2016.
  5. Asada K, Nakajima T, Shimazu T, Yamamichi N, Maekita T, Yokoi C, Oda I, Ando T, Yoshida T, Nanjo S, Fujishiro M, Gotoda T, Ichinose M, Ushijima T. Gut. 64: 388-396, 2015.
  6. Chen YI, Levy MJ, Moreels TG, Hajijeva G, Will U, Artifon EL, Hara K, Kitano M, Topazian M, Abu Dayyeh B, Reichel A, Vilela T, Ngamruengphong S, Haito-Chavez Y, Bukhari M, Okolo P 3rd, Kumbhari V, Ismail A, Khashab MA. An international multicenter study comparing EUS-guided pancreatic duct drainage with enteroscopy-assisted endoscopic retrograde pancreatography after Whipple surgery. Gastrointest Endosc 2016 in press
  7. Deguchi H, Kato J, Maeda Y, Moribata K, Shingaki N, Niwa T, Inoue I, Maekita T, Iguchi M, Tamai H, Ichinose M. Argon plasma coagulation is effective for prevention of recurrent esophageal varices after endoscopic injection sclerotherapy: A single-center case-control study. Dig Emdosc. 28: 42-49, 2016.
  8. Fukatsu K, Kato J, Niwa　T, Iguchi M, Muraki Y, Maekita T,Inoue I, Tamai H, Deguchi H, Moribata K, Maeda Y, Nakamura Y, Murata S, Ichinose M. Microscopic invasion patterns and epithelial cell-phenotypes in early gastric cancer with submucosal invasion. Journal of Cytology & Histology. (2016) in press.
  9. Hiraoka S, Kato J, Moritou Y, Takei D, Inokuchi T, Nakarai A, Takahashi S, Harada K, Okada H, Yamamoto K: The earliest trough concentration predicts the dose of tacrolimus required for remission induction therapy in ulcerative colitis patients. BMC Gastroenterol, 15:53, 2015
  10. Kamata K, Kitano M, Omoto S, Kadosaka K, Miyata T, Yamao K, Imai H, Sakamoto H, Harwani Y, Chikugo T, Chiba Y, Matsumoto I, Takeyama Y, Kudo M: Contrast-enhanced harmonic endoscopic ultrasonography for differential diagnosis of pancreatic cysts. Endoscopy 48:35-41, 2016
  11. Kamata K, Kitano M, Yasukawa S, Kudo M, Chiba Y, Ogura T, Higuchi K, Fukutake N, Ashida R, Yamasaki T, Nebiki H, Hirose S, Hoki N, Asada M, Yazumi S, Takaoka M, Okazaki K, Matsuda F, Okabe Y, Yanagisawa A. Histologic diagnosis of pancreatic masses using 25-gauge endoscopic ultrasound needles with and without a core trap: a multicenter randomized trial. Endoscopy. 2016; 48: 632-8.
  12. Kanno A, Masamune A, Fujishima F, Iwashita T, Kodama Y, Katanuma A, Ohara H, Kitano M, Inoue H, Itoi T, Mizuno N, Miyakawa H, Mikata R, Irisawa A, Sato S, Notohara K, Shimosegawa T. Diagnosis of autoimmune pancreatitis by EUS-guided FNA using a 22-gauge needle: a prospective multicenter study. Gastrointest Endosc. 84:797-804, 2016.
  13. Komeda Y, Kashida H, Sakurai T, Tribonias G, Okamoto K, Kono M, Yamada M, Adachi T, Mine H, Nagai T, Asakuma Y, Hagiwara S, Matsui S, Watanabe T, Kitano M, Chikugo T, Chiba Y, Kudo M. Removal of diminutive colorectal polyps: A prospective randomized clinical trial between cold snare polypectomy and hot forceps biopsy. World J Gastroenterol 2016 in press
  14. Imai H, Kitano M, Omoto S, Kadosaka K, Kamata K, Miyata T, Yamao K, Sakamoto H, Harwani Y, Kudo M. EUS-guided gallbladder drainage for rescue treatment of malignant distal biliary obstruction after unsuccessful ERCP. Gastrointest Endosc. 2016; 84: 147-51.
  15. Maeda Y, Moribata K, Deguchi H, Inoue I, Maekita T, Iguchi M, Tamai H, Kato J, Ichinose M. Video capsule endoscopy as the initial examination for overt obscure gastrointestinal bleeding can efficiently identify patients who require double-balloon enteroscopy. BMC Gastroenterol. 15:132. 2015 Oct 14 doi: 10.1186 /s12876-015-0362-7.
  16. Maekita T, Kato J,Enomoto S,Yoshida T,Utsunomiya H,Hayashi H, Hanamitsu T, Inoue I, Maeda Y, Moribata K, Muraki Y, Shingaki N, Deguchi H,Ueda K, Iguchi M, Tamai H, Ichinose M : Japanese apricot improves symptoms of gastrointestinal dysmotility associated with gastroesophageal reflux disease. World Journal of Gastroenterology: 21(26): 8170-8177, 2015
  17. Maekita T, Nakazawa K, Kato J: Migration of gastrostomy site: Rare complication of percutaneous endoscopic gastrostomy. Digestive Endoscopy: 27(3): 397–401, 2015
  18. Matsui S, Kudo M, Kitano M, Asakuma Y: Evaluation of the response to chemotherapy in advanced gastric cancer by contrast-enhanced harmonic EUS. Hepato-Gastroenterol 62: 595-8, 2015
  19. Miyata T, Kitano M, Omoto S, Kadosaka K, Kamata K, Imai H, Sakamoto H, Nisida N, Harwani Y, Murakami T, Takeyama Y, Chiba Y, Kudo M. Contrast-enhanced harmonic endoscopic ultrasonography for assessment of lymph node metastases in pancreatobiliary carcinoma. World J Gastroenterol. 2016; 22: 3381-91.
  20. Minaga K, Kitano M, Imai H, Yamao K, Kamata K, Miyata T, Omoto S, Kadosaka K, Yoshikawa T, Kudo M. Urgent endoscopic ultrasound-guided choledochoduodenostomy for acute obstructive suppurative cholangitis-induced sepsis.　World J Gastroenterol. 22: 4264-9, 2016
  21. Minaga K, Kitano M, Imai H, Harwani Y, Yamao K, Kamata K, Miyata T, Omoto S, Kadosaka K, Sakurai T, Nishida N, Kudo M. Evaluation of anti-migration properties of biliary covered self-expandable metal stents. World J Gastroenterol 2016; 22: 6917-6924.
  22. Minaga K, Kitano M, Gon C, Yamao K, Imai H, Miyata T, Kamata K, Omoto S, Takenaka M, Kudo M. Endoscopic ultrasonography-guided choledochoduodenostomy using a newly designed laser-cut metal stent: Feasibility study in a porcine model. Dig Endosc. 2016 in press
  23. Minaga K, Kitano M, Sakamoto H, Miyata T, Imai H, Yamao K, Kamata K, Omoto S, Kadosaka K, Sakurai T, Nishida N, Chiba Y, Kudo M. Predictors of pain response in patients undergoing endoscopic ultrasound-guided neurolysis for abdominal pain caused by pancreatic cancer. Therap Adv Gastroenterol. 9: 483-94, 2016.
  24. Mori G, Nakajima T, Asada K, Shimazu T, Yamamichi N, Maekita T, Yokoi C, Fujishiro M, Gotoda T, Ichinose M, Ushijima T, Oda I: Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan. Gastric Cancer 19:911-8, 2016
  25. Mori Y, Tamai H, Shingaki N, Hayami S, Ueno M, Maeda Y, Moribata K, Deguchi H, Niwa T, Inoue I, Maekita T, Iguchi M, Kato J, Terada M, Yamaue H, Ichinose M. Hypointense hepatocellular carcinomas on apparent diffusion coefficient mapping: Pathologic features and metastatic recurrence after hepatectomy. Hepatol Res. 46:634-41, 2016
  26. Mori Y, Tamai H, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Terada M, Ichinose M. Signal intensity of small hepatocellular carcinoma on apparent diffusion coefficient mapping and outcome after radiofrequency ablation. Hepatol Res. 45(1):75-87, 2015.
  27. Moribata K, Kato J, Iguchi M, Nakachi K, Maeda Y, Shingaki N, Niwa T, Deguchi H, Inoue I, Maekita T, Tamai H, Ichinose M. Endoscopic features associated with development of metachronous gastric cancer in patients who underwent endoscopic resection followed by Helicobacter pylori eradication. Digestive Endoscopy 2015 doi: 10.1111.
  28. Naganawa K, Takayama E, Adachi M, Mitsudo K, Iida M, Kamiya-Mizuno M, Kawaki H, Ichinose M, Motohashi M, Muramatsu Y, Tohnai I, Sumitomo S, Shikimori M, Kondoh N. Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients. Open Dent J. 9: 120-4, 2015.
  29. Nishida N, Iwanishi M, Minami T, Chishina H, Arizumi T, Takita M, Kitai S, Yada N, Ida H, Hagiwara S, Minami Y, Ueshima K, Sakurai T, Kitano M, Kudo M: Hepatic DNA methylation is affected by hepatocellular carcinoma risk in patients with and without hepatitis virus. Dig Dis 33: 745-750, 2015
  30. Nishida N, Iwanishi M, Minami T, Chishina H, Arizumi T, Takita M, Kitai S, Yada N, Ida H, Hagiwara S, Minami Y, Ueshima K, Sakurai T, Kitano M, Kudo M: Early viral response predicts the efficacy of antiviral triple therapy with simeprevir, Peg-interferon and Ribavirin in patients infected with hepatitis C virus genotype 1. Dig Dis 33: 708-714, 2015
  31. Nishida N, Iwanishi M, Minami T, Chishina H, Arizumi T, Takita M, Kitai S, Yada N, Ida H, Hagiwara S, Minami Y, Ueshima K, Sakurai T, Kitano M, Kudo M: Hepatic DNA methylation is affected by hepatocellular carcinoma risk in patients with and without hepatitis virus. Dig Dis 33: 745-750, 2015
  32. Nishida N, Yada N, Hagiwara S, Sakurai T, Kitano M, Kudo M. Unique features associated with hepatic oxidative DNA damage and DNA methylation in non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 31:1646-53. 2016
  33. Nuta J, Tamai H, Mori Y, Shingaki N, Maeshima S, Shimizu R, Maeda Y, Moribata K, Niwa T, Deguchi H, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M. Kupffer Imaging by Contrast-Enhanced Sonography With Perfluorobutane Microbubbles Is Associated With Outcomes After Radiofrequency Ablation of Hepatocellular Carcinoma. J Ultrasound Med. 35(2):359-71, 2016.
  34. Ogura T, Chiba Y, Masuda D, Kitano M, Sano T, Saori O, Yamamoto K, Imaoka H, Imoto A, Takeuchi T, Fukunishi S, Higuch K: Comparison of the clinical impact of endoscopic ultrasound-guided choledochoduodenostomy and hepaticogastrostomy for bile duct obstruction with duodenal obstruction. Endoscopy 48:156-163. 2016
  35. Ogura T, Sano T, Onda S, Imoto A, Masuda D, Yamamoto K, Kitano M, Takeuchi T, Inoue T, Higuchi K: Endoscopic ultrasound-guided biliary drainage for right hepatic bile duct obstruction: novel technical tips. Endoscopy. 47: 72-75, 2015
  36. Ogura T, Masuda D, Saori O, Wataru T, Sano T, Okuda A, Miyano A, Kitano M, Abdel-Aal UM, Takeuchi T, Fukunishi S, Higuchi K: Clinical Outcome of Endoscopic Ultrasound-Guided Liver Abscess Drainage Using Self-Expandable Covered Metallic Stent (with Video). Dig Dis Sci 61:303-8, 2016
  37. Ogura T, Onda S, Takagi W, Kitano M, Sano T, Okuda A, Miyano A, Masuda D, Takeuchi T, Fukunishi S, Higuchi K. Placement of a 6 mm, fully covered metal stent for main pancreatic head duct stricture due to chronic pancreatitis: a pilot study (with video). Therap Adv Gastroenterol. 9:722-8, 2016
  38. Ogura T, Onda S, Takagi W, Sano T, Okuda A, Masuda D, Yamamoto K, Miyano A, Kitano M, Takeuchi T, Fukunishi S, Higuchi K. Clinical utility of Endoscopic ultrasound-guided biliary drainage as a rescue of re-intervention procedure for high-grade hilar stricture. J Gastroenterol Hepatol. 2016 in press
  39. Obara K, Haruma K, Irisawa A, Kaise M, Gotoda T, Sugiyama M, Tanabe S, Horiuchi A, Fujita N, Ozaki M, Yoshida M, Matsui T, Ichinose M, Kaminishi M. Guidelines for Sedation in Gastroenterological Endoscopy. Dig Endosc. 27: 435-449, 2015.
  40. Ono H, Yao K, Fujishiro M, Oda I, Nimura S, Yahagi N, Iishi H, Oka M, Ajioka Y, Ichinose M, Matsui T. Guidelines for ESD and EMR for Early Gastric Cancer. Dig Endoscopy 28:3-15, 2016
  41. Sakurai T, Kashida H, Komeda Y, Nagai T, Hagiwara S, Watanabe T, Kitano M, Nishida N, Fujita J, Kudo M. Stress Response Protein RBM3 Promotes the Development of Colitis-associated Cancer. Inflamm Bowel Dis. 2016 in press
  42. Shagdarsuren B, Tamai H, Shingaki N, Mori Y, Maeshima S, Nuta J, Maeda Y, Moribata K, Niwa T, Deguchi H,Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M. The contribution of contrast-enhanced ultrasound with perfluorobutane microbubbles in the diagnosis of recurrent HCC. J Ultrasound Med. 35:1363-91, 2016.
  43. Shimizu R, Tamai H, Mori Y, Shingaki N, Maeshima S, Nuta J, Maeda Y, Moribata K, Muraki Y, Deguchi H, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M. The arterial tumor enhancement pattern on contrast-enhanced computed tomography is associated with primary cancer death after radiofrequency ablation for small hepatocellular carcinoma. Hepatol Int. 10:328-39, 2016
  44. Tabuse H, Kashiwagi H, Hamauchi S, Tsushima T, Todaka A, Yokota T, Machida N, Yamazaki K, Fukutomi A, Onozawa Y, Mori K, Boku N, Ichinose M, Yasui H. Excessive watering eyes in gastric cancer patients receiving S-1 chemotherapy. Gastric Cancer 19:894-901, 2016
  45. Takashima S, Kato J, Hiraoka S, Nakarai A, Takei D, Inokuchi T, Sugihara Y, Takahara M, Harada K, Okada H, Tanaka T, Yamamoto K: Evaluation of mucosal healing in ulcerative colitis by fecal calprotectin vs. fecal immunochemical test. Am J Gastroenterol. 110, 873-880, 2015
  46. Tamai H, Mori Y, Shingaki N, Shimizu R, Nuta J, Moribata K, Maeda Y, Muraki Y, Deguchi H, Inoue I, Maekita T, Iguchi M, Kato J, Takifuji K, Yamaue H, Ichinose M; Prognostic effect of response to interferon therapy after laparoscopic splenectomy among patients with marked thrombocytopenia and hepatitis C virus-related cirrhosis. Hapatol Int 9: 67-75, 2015.
  47. Tamai H, Shingaki N, Mori Y, Moribata K, Kawashima A, Maeda Y, Niwa T, Deguchi H, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M. Low-dose pegylated interferon α-2b plus ribavirin for elderly and/or cirrhotic patients with genotype 2 hepatitis C virus. Gut Liver. 10:617-23, 2016
  48. Tanaka S, Kashida H, Saito Y, Yahagi N, Yamamo H, Saito S, Hisabe T, Yao T, Watanabe M, Yoshida M, Kudo SE, Tsuruta O, Sugihara KI, Watanabe T, Saitoh Y, Igarashi M, Toyonaga T, Ajioka Y, Ichinose M, Matsui T, Sugita A, Sugano K, Fujimoto K, Tajiri H. (JGES Guideline) Colorectal endoscopic submucosal dissection / endoscopic mucosal resection guidelines. Dig Endosc. 27:417-34, 2015
  49. Togashi Y, Kogita A, Sakamoto H, Hayashi H, Terashima M, de Velasco MA, Sakai K, Fujita Y, Tomida S, Kitano M, Okuno K, Kudo M, Nishio K: Activin signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer. Cancer Lett 356(2 Pt B): 819-827, 2015
  50. Ueno M, Hayami S, Shigekawa Y, Kawai M, Hirono S, Okada K, Tamai H, Shingaki N, Mori Y, Ichinose M, Yamaue H. Prognostic impact of surgery and radiofrequency ablation on single nodular HCC ?5 cm: Cohort study based on serum HCC markers. J Hepatol. 63(6):1352-9, 2015.
  51. Yamashita Y, Kato J, Ueda K, Nakamura Y, Abe H, Tamura T, Itonaga M, Yoshida T, Maeda H, Moribata K, Niwa T, Maekita T, Iguchi M, Tamai H, Ichinose M : Contrast-enhanced endoscopic ultrasonography can predict a higher malignant potential of gastrointestinal stromal tumors by visualizing large newly formed vessels. J Clin Ultrasound. 2015 Feb;43(2):89-97.
  52. Yamashita Y, Kato J, Ueda K, Nakamura Y, Kawaji Y, Abe H, Nuta J, Tamura T, Itonaga M, Yoshida T, Maeda H, Maekita T, Iguchi M, Tamai H, Ichinose M: Contrast-Enhanced Endoscopic Ultrasonography for Pancreatic Tumors. Biomed Res Int. 2015;2015:491782. doi: 10.
  53. Yamashita Y, Ueda K, Kawaji Y, Tamura T, Itonaga M, Yoshida T, Maeda H, Magari H, Maekita T, Iguchi M, Tamai H, Ichinose M, Kato J. The Wire-grasping method as a new technique for forceps biopsy of biliary strictures: the wire-grasping method; A prospective randomized controlled study of effectiveness. Gut and Liver. 10:642-8, 2016.
  54. Yamao K, Kitano M, Kayahara T, Ishida E, Yamamoto H, Minaga K, Yamashita Y, Nakajima J, Asada M, Okabe Y, Osaki Y, Chiba Y, Imai H, Kudo M. Factors predicting through-the-scope gastroduodenal stenting outcomes in patients with gastric outlet obstruction: a large multicenter retrospective study in West Japan. Gastrointest Endosc. 2016 in press
  55. Yoshida S, Yamashita S, Niwa T, Mori A, Ito S, Ichinose M, Ushijima T. Epigenetic Inactivation of FAT4 Contributes to Gastric Field Cancerization. Gastric Cancer (2016) in press.
  1. Fujimoto K, Fujishiro M, Kato M, Higuchi K, Iwakiri R, Sakamoto C, Uchiyama S, Kashiwagi A, Ogawa H, Murakami K, Mine T, Yoshino J, Kinoshita Y, Ichinose M, Matsui T. Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment. Dig Endosc. 26; 1-14, 2014.
  2. Higuchi K, Takeuchi T, Uedo N, Takeuchi Y, Yagi N, Tominaga K, Machida H, Tamada T, Morita Y, Yazumi S, Yamao J, Iguchi M, Azuma T: Efficacy and safety of 1-week Helicobacter pylori eradication therapy and 7-week rebamipide treatment after endoscopic submucosal dissection of early gastric cancer in comparison with 8-week PPI standard treatment: a randomized, controlled, prospective, multicenter study. Gastric cancer, 18:612-7, 2015
  3. Iida M, Takayama E, Naganawa K, Mitsudo K, Adachi M, Baba J, Fujimoto- Muto M, Motohashi M, Mizuno-Kamiya M, Kawaki H, Kioi M, Ichinose M, Sumitomo S, Muramatsu Y, Shikimori M, Tohnai I, Kondoh N; Increase of Peripheral Blood CD57+ T-Cells in Patients with Oral Squamous Cell Carcinoma. Anticancer Res 34: 5729-5734, 2014.
  4. Inokuchi T, Kato J, Hiraoka S, Suzuki H, Nakarai A, Hirakawa T, Akita M, Takahashi S, Harada K, Okada H, Yamamoto K: Long-term follow-up of ulcerative colitis patients treated on the basis of their cytomegalovirus antigen status. World J Gastroenterol, 20, 509-517, 2014
  5. Inoue I, Kato J, Tamai H, Iguchi M, Maekita T, Yoshimura N, Ichinose M: Helicobacter pylori-related chronic gastritis as a risk factor for colonic neoplasms. World Journal of Gastroenterology (WJG 20th Anniversary Special Issue(6): Helicobacrer pylori) 20(6); 1485-1492, 2014.
  6. Kageyama-Yahara N, Yamamichi N, Takahashi Y, Nakayama C, Shiogama K, Inada KI, Konno-Shimizu M, Kodashima S, Fujishiro M, Tsutsumi Y, Ichinose M, Koike K. Gli Regulates MUC5AC Transcription in Human Gastrointestinal Cells. PLoS One. 9:e106106, 2014
  7. Kamata K, Kitano M, Kudo M, Sakamoto H, Kadosaka K, Miyata T, Imai H, Maekawa K, Chikugo T, Kumano M, Hyodo T, Murakami T, Chiba Y, Takeyama Y: Value of EUS in early detection of pancreatic ductal adenocarcinomas in patients with intraductal papillary mucinous neoplasms. Endoscopy 46: 22-29, 2014
  8. Kanai F, Obi S, Fujiyama S, Shiina S, Tamai H, Mochizuki H, Koike K, Imamura J, Yamaguchi T, Saida I, Yokosuka O, Omata M.An open-label phase I/II study of tamibarotene in patients with advanced hepatocellular carcinoma. Hepatol Int. 2014; 8:94–103.
  9. Kurimoto M, Sonoki T, Nakamura Y, Yamamoto Y, Maeda Y, Kuriyama K, Mushino T, Hosoi H, Murata S, Shimanuki M, Hatanaka K, Hanaoka N, Kato J, Nakakuma H: Severe enteropathy caused by a-heavy chain disease lacking detectable M-proteins. Intern Med. 53, 581-585, 2014
  10. Mori Y, Tamai H, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Terada M and Ichinose M Signal intensity of small hepatocellular carcinoma on apparent diffusion coefficient mapping and outcome after radiofrequency ablation. Hepatol Res Hepatol Res.45:75-87, 2014
  11. Mori Y, Tamai H, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Terada M, Ichinose M. Signal intensity of small hepatocellular carcinoma on apparent diffusion coefficient mapping and outcome after radiofrequency ablation. Hepatol Res. 45:75-87, 2014
  12. Nakachi K, Tamai H, Mori Y, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J and Ichinose M. Prediction of poorly differentiated hepatocellular carcinoma using contrast computed tomography. Cancer Imaging 14:7, 2014.
  13. Nakarai A, Kato J, Hiraoka S, Inokuchi T, Takei D, Morito Y, Akita M, Takahashi S, Hori K, Harada K, Okada H, Yamamoto K: Slight increases in desease activiety index and platelet count imply the presence of active intestinal lesions in C-reactive protein negative Crohn's disease patients. Intern Med. 53: 1905-1911, 2014
  14. Sonomura T, Kawai N, Kishi K, Ikoma A, Sanda H, Nakata K, Minamiguchi H, Nakai M, Hosokawa S, Tamai H, Sato M. N-butyl cyanoacrylate embolization with blood flow control of an arterioportal shunt that developed after radiofrequency ablation of hepatocellular carcinoma. Korean J Radiol. 2014 Mar-Apr;15(2):250-3.
  15. Takao Maekita, Kazuyuki Nakazawa and　Jun Kato: Migration of gastrostomy site: Rare complication of percutaneous endoscopic gastrostomy. Digestive Endoscopy. 27:398-9, 2015
  16. Tamai H, Mori Y, Shingaki N, Kawashima A, Tsukuda H, Higashi K, Moribata K, Kawaguchi M, Ueda K, Deguchi H, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M.　Low-dose pegylated interferon-α-2a plus ribavirin therapy for elderly and/or cirrhotic patients with hepatitis C virus genotype-1b and high viral load. Antivir Ther. 2014;19(1):107-15.
  17. Tamai H, Mori Y, Shingaki N, Shimizu R, Nuta J, Moribata K, Maeda Y, Muraki Y, Deguchi H, Inoue I, Maekita T, Iguchi M, Kato J, Takifuji K, Yamaue H, Ichinose M. Prognostic effect of response to interferon therapy after laparoscopic splenectomy among patients with marked thrombocytopenia and hepatitis C virus-related cirrhosis. Hepatol Int 9:67-75, 2014
  18. Tamai H, Shimizu R, Shingaki N, Mori Y, Maeshima S, Nuta J, Maeda Y, Moribata K, Muraki Y, Deguchi H, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M. Prediction of Sustained Virological Response to Telaprevir-Based Triple Therapy Using Viral Response within 2 Weeks. Hepat Res Treat. 2014:748935, 2014.
  19. Tamai H, Shimizu R, Shingaki N, Mori Y, Maeshima S, Nuta J, Maeda Y, Moribata K, Muraki Y, Deguchi H, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M: Prediction of sustained virological response to Telaprevir-based triple therapy using viral response within 2 weeks. Hepat Res Treat 2014:748935, 2014
  20. Utsunomiya H, Ichinose M, Ikeda K, Uozaki M, Morishita J, Kuwahara T, Koyama AH, and Yamasaki H; Inhibition by caffeic acid of the influenza A virus multiplication in vitro. Internatinal Journal of Molecular Medicine 34:1020-1024, 2014.
  21. Wada Y, Tamai H, Kawashima A, Shingaki N, Mori Y, Kawaguchi M, Moribata K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M: Prediction of a null response to pegylated interferon-α-2b plus ribavirin in patients with high viral load genotype 1b hepatitis C. Gut Liver 8(4); 421-27, 2014.
  22. Wada Y, Tamai H, Uno A, Kawashima A, Shingaki N, Mori Y, Moribata K, Miyata K, Higashi K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M: Prediction of efficacy pegylated interferon-alpha-2b plus ribavirin in patients with genotype 2 hepatitis C virus using viral response within 2 weeks. Hepatol Res 44(2); 179-186, 2014.
  23. Yamamichi N, Hirano C, Shimamoto T, Minatsuki C, Takahashi Y, Nakayama C, Matsuda R, Fujishiro M, Konno-Shimizu M, Kato J, Kodashima S, Ono S, Niimi K, Mochizuki S, Tsuji Y, Sakaguchi Y, Asada-Hirayama I, Takeuchi C, Yakabi S, Kakimoto H, Wada R, Mitsushima T, Ichinose M, Koike K. Associated factors of atrophic gastritis diagnosed by double-contrast upper gastrointestinal barium X-ray radiography: a cross-sectional study analyzing 6,901 healthy subjects in Japan.　PLoS One. 9(10): e111359, 2014.
  24. Yamashita Y, Kato J, Ueda K, Nakamura Y, Abe H, Tamura T, Itonaga M, Yoshida T, Maeda H, Moribata K, Niwa T, Maekita T, Iguchi M, Tamai H, Ichinose M. Contrast-enhanced endoscopic ultrasonography can predict a higher malignant potential of gastrointestinal stromal tumors by visualizing large newly formed vessels. J Clin Ultrasound. 2014 Jul 16. doi: 10.1002
  25. Yamashita Y, Ueyama T, Nishi T, Yamamoto Y, Kawakoshi A, Sunami S, Iguchi M, Tamai H, Ueda K, Ito T, Tsuruo Y, Ichinose M. Nrf2-inducing anti-oxidation stress response in the rat liver--new beneficial effect of lansoprazole. PLoS One. 9:e97419, 2014.
  26. Yamaue H, Satoi S, Kanbe T, Miyazawa M, Tani M, Kawai M, Hirono S, Okada K, Yanagimoto H, Kwon AH, Mukouyama T, Tsunoda H, Chijiiwa K, Ohuchida J, Kato J, Ueda K, Yamaguchi T, Egawa S, Hayashi K, Shirasaka T: Phase II clinical study of alternate-day oral therapy with S-1 as first-line chemotherapy for locally advanced and metastatic pancreatic cancer. Cancer Chemother Pharmacol, 73, 97-102, 2014
  27. Yoshida T, Kato J, Inoue I, Yoshimura N, Deguchi H, Mukoubayashi C, Oka M, Watanabe M, Enomoto S, Niwa T, Maekita T, Iguchi M, Tamai H, Utsunomiya H, Yamamichi N, Fujishiro M, Iwane M, Takeshita T, Ushijima T, Ichinose M：Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer.　Int J Cancer. 134 (6), 1445-1457, 2014
  1. Akita M, Hiraoka S, Kaji E, Takemoto K, Nagahara Y, Yamamoto H, Yamamoto K, Kato J. Is presence or history of extracolonic primary malignancy a risk for colorectal neoplasia? An analysis of patients who underwent colonoscopy. Acta Med Okayama 67, 285-292, 2013
  2. Asada K, Ando K, Niwa T, Nanjo S, Watanabe N, Okochi-Takada E, Yoshida T, Miyamoto K, Enomoto S, Ichinose M, Tsukamoto T, Ito S, Tatematsu M, Sugiyama T, Ushijima T; FHL1 on chromosome X is a single-hit gastrointestinal tumor-suppressor gene and contributes to the formation of an epigenetic field defect. Oncogene 32:2140-2149,2013.
  3. Das K, Kudo M, Kitano M, Sakamoto H, Komaki T, Takagi T, Yamao K: Diagnostic value of endoscopic ultrasound-guided directional eFLOW in solid pancreatic lesions. J Med Ultrasonics 40: 211-218, 2013
  4. Enomoto　S, Maekita T, Nakazawa K, Yoshida T, Watanabe M, Mukoubayashi C, Ohata H, Iguchi M, Yanaoka K , Tamai H, Kato J, Oka M, Mohara O, Ichinose M. Gastric Cancer Risk Diagnosis Using Molecular Biological and Serological Markers Based on Helicobacter pylori-Related Chronic Gastritis. Current Topics in Gastritis - 2012", p183-200, book edited by Gyula Mozsik, ISBN 978-953-51-0907-5, Published: January 16, 2013
  5. Fujimoto K, Fujishiro M, Kato M, Higuchi K, Iwakiri R, Sakamoto C, Uchiyama S, Kashiwagi A, Ogawa H, Murakami K, Mine T, Yoshino J, Kinoshita Y, Ichinose M, Matsui T. Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment. Dig Endosc. 26:1-4, 2014
  6. Fukamachi H, Kato S, Asashima M, Ichinose M, Yuasa Y. Activin A regulates growth of gastro-intestinal epithelial cells by mediating epithelial-mesenchymal interaction. Dev Growth Differ. 55:786-91, 2013
  7. Hirakawa T, Kato J, Takahashi S, Suzuki H, Akita M, Inoue I, Deguchi H, Hiraoka S, Okada H, Yamamoto K. : Disparity in clinical care for patients with inflammatory boweld disease between specialists and non-specialists. Open J Gastroenterol, 3;64-71, 2013
  8. Ichinose M, Watanabe M, Kato J. Re: Development of diffuse carcinoma in the gastric corpus in patients with rugal hyperplastic gastritis. Int J Cancer. 113:2259, 2013
  9. Inoue I, Kato J, Yoshimura N, Maeda Y, Moribata K, Shingaki N, Deguchi H, Enomoto S, Maekita T, Ueda K, Iguchi M, Tamai H, Fujishiro M, Yamamichi N, Takeshita T, Ichinose M; Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori associated chronic atrophic gastritis: A follow up study of patients with endoscopically resected colorectal neoplasia. Mol Clin Oncol 1; 75-82, 2013.
  10. Kanai F, Obi S, Fujiyama S, Shiina S, Tamai H, Mochizuki H, Koike K, Imamura J, Yamaguchi T, Saida I, Yokosuka O, Omata M. An open-label phase I/II study of tamibarotene in patients with advanced hepatocellular carcinoma　Hepatol Int　9:94-103, 2014
  11. Kato J, Hiraoka S, Nakarai A, Ichinose M : Noninvasive evaluation of mucosal healing in inflammatory bowel diseases. Clin J Gastroenterol 6:1-7, 2013
  12. Kim JG, Takeshima H, Niwa T, Rehnberg E, Shigematsu Y, Yoda Y, Yamashita S, Kushima R, Maekita T, Ichinose M, Katai H, Park WS, Hong YS, Park CH, Ushijima T; Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. Cancer Lett. 330; 33-40, 2013.
  13. Kitano M, Yamashita Y, Tanaka K, Konishi H, Yazumi S, Nakai Y, Nishiyama O, Uehara H, Mitoro A, Sanuki T, Takaoka M, Koshitani T, Arisaka Y, Shiba M, Hoki N, Sato H, Sasaki Y, Sato M, Hasegawa K, Kawabata H, Okabe Y, Mukai H: Covered self-expandable metal stents with an anti-migration system improve patency duration without increased complications compared with uncovered stents for distal biliary obstruction caused by pancreatic carcinoma: a randomized multicenter trial. Am J Gastroenterol 108: 1713-1722, 2013
  14. Konno-Shimizu M, Yamamichi N, Inada K, Kageyama-Yahara N, Shiogama K, Takahashi Y, Asada-Hirayama I, Yamamichi-Nishina M, Nakayama C, Ono S, Kodashima S, Fujishiro M, Tsutsumi Y, Ichinose M, Koike K. Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis.　PLoS One. 8; e56766, 2013.
  15. Maekita T, Kato J, Nakatani Y, Enomoto S, Kayama T, Tsuji M, Nakaya T, Muraki Y, Deguchi H, Ueda K, Inoue I, Iguchi M, Tamai H, Ichinose M. Usefulness of a continuous suction mouthpiece during percutaneous endoscopic gastrostomy: A single-center, prospective, randomized study. Dig Endosc. 25:496-501, 2013.
  16. Maekita T, Kato J, Nakatani Y, Enomoto S, Takano E, Tsuji M, Nakaya T, Moribata K, Muraki Y, Shingaki N, Niwa T, Deguchi H, Ueda K, Inoue I, Iguchi M, Tamai H, Ichinose M. Usefulness of continuous suction mouthpiece during esophagogastroduodenoscopy: A single-center, prospective, randomized study. World J Gastrointest Endosc 5: 508-513, 2013.
  17. Matsuda K, Takifuji K, Hotta T, Yokoyama S, Ieda J, Arii K, Ichinose M, Nakamura Y, Yasuoka H, Yamaue H: Angiosarcoma involving colon and bone successfully responded to paclitaxel and zoledronate : case report. Clin J Gastroenterol 6; 20-24, 2013
  18. Mori Y, Tamai H, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Terada M, Ichinose M; Detection of hypervascular hepatocellular carcinoma with non-enhanced magnetic resonance imaging including diffusion-weighted imaging. Journal of Gastroenterology and Hepatology Research 21; 473-478, 2013
  19. Nakarai A, Kato J, Hiraoka S, Kuriyama M, Akita M, Hirakawa T, Okada H, Yamamoto K: Evaluation of mucosal healing of ulcerative colitis by a quantitative fecal immunochemical test. Am J Gastroenterol, 108: 83-9, 2013
  20. Shigematsu Y, Niwa T, Rehnberg E, Toyoda T, Yoshida S, Mori A, Wakabayashi M, Iwakura Y, Ichinose M, Kim YJ, Ushijima T; Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. Cancer Lett. 340; 141-147, 2013.
  21. Shingaki N, Tamai H, Mori Y, Moribata K, Enomoto S, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J and Ichinose M. Serological and histological indices of hepatocellular carcinoma and tumor volume doubling time. Molecular and Clinical Oncology 1; 977-981, 2013.
  22. Tamai H, Mori Y, Shingaki N, Kawashima A, Tsukuda H, Katsuhiko H, Moribata K, Kawaguchi M, Ueda K, Deguchi H, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M. Low-dose pegylated interferon-α-2a plus ribavirin therapy for elderly and/or cirrhotic patients with hepatitis C virus genotype-1b and high viral load. Antivir Ther. 19:107-15, 2014
  23. Tamai H, Moribata K, Mori Y, Shingaki N, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M; Low-dose pegylated interferon-alpha-2a monotherapy in elderly and/or cirrhotic patients infected with hepatitis C virus genotype-2 or genotype-1 low level infection. Hepatol Res. 43:702-708, 2013.
  24. Togashi Y, Sakamoto H, Hayashi H, Terashima M, de Velasco MA, Fujita Y, Kodera Y, Sakai K, Tomida S, Kitano M, Ito A, Kudo M, Nishio K*: Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer. Mol Cancer 13: 126, 2014
  25. Ueno H, Ioka T, Ikeda M, Ohkawa S, Yanagimoto H, Boku N, Fukutomi A, Sugimori K, Baba H, Yamao K, Shimamura T, Sho M,　Kitano M, Cheng AL, Mizumoto K, Chen JS, Furuse J, Funakoshi A, Hatori T, Yamaguchi T, Egawa S, Sato A, Ohashi Y, Okusaka T, Tanaka M: Randomized Phase III Study of Gemcitabine Plus S-1, S-1 Alone, or Gemcitabine Alone in Patients With Locally Advanced and Metastatic Pancreatic Cancer in Japan and Taiwan: GEST Study. J Clin Oncol 31: 1640-1648, 2013
  26. Ueyama T, Yamamoto Y, Ueda K, Yajima A, Maeda Y, Yamashita Y, Ito T, Tsuruo Y, Ichinose M; Is gastrectomy-induced high turnover of bone with hyperosteoidosis and increase of mineralization a typical osteomalacia? PLoS One. 8(6):e65685, 2013.
  27. Wada Y, Tamai H, Uno A, Kawashima A, Shingaki N, Mori Y, Moribata K, Miyata K, Higashi K, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J and Ichinose M; Prediction of efficacy to pegylated interferon α-2b plus ribavirin in patients with genotype-2 hepatitis C virus using viral response within two weeks. Hepatol Res 44; 179-186, 2013.
  28. Yamashita Y, Ueda K, Itonaga M, Yoshida T, Maeda H, Maekita T, Iguchi M, Tamai H, Ichinose M, Kato J; Usefulness of contrast-enhanced endoscopic sonography for discriminating mural nodules from mucous clots in intraductal papillary mucinous neoplasms: a single-center prospective study. J Ultrasound Med. 32; 61-8, 2013.
  29. Yamashita Y, Ueda K, Itonaga M, Yoshida T, Maeda H, Maekita T, Iguchi M, Tamai H, Ichinose M, Kato J; Tumor vessel depiction with contrast-enhanced endoscopic ultrasonography predicts efficacy of chemotherapy in pancreatic cancer. Pancreas. 42; 990-5, 2013.
  30. Yasuda I, Nakashima M, Iwai T, Isayama H, Itoi T, Hisai H, Inoue H, Kato H, Kanno A, Kubota K, Irisawa A, Igarashi H, Okabe Y, Kitano M, Kawakami H, Hayashi T, Mukai T, Sata N, Kida M, Shimosegawa T: Japanese multicenter experience of endoscopic necrosectomy for infected walled-off pancreatic necrosis: The JENIPaN study. Endoscopy 45: 627-634, 2013
  31. Yasunobu Yamashita, Kazuki Ueda, Hiroko Abe, Takashi Tamura, Masahiro Itonaga, Takeichi Yoshida, Hiroki Maeda, Takao Maekita, Mikitaka Iguchi, Hideyuki Tamai, Jun Kato , Masao Ichinose. Common Bile Duct Dilatation With Stones Indicates Requirement for Early Drainage in Patients With or Without Cholangitis Gastroenterology Research. 2013;6(6):219-226.
  32. Yoshida T, Kato J, Maekita T, Yamashita S, Enomoto S, Ando T, Niwa T, Deguchi H, Ueda K, Inoue I, Iguchi M, Tamai H, Ushijima T, Ichinose M. Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis. Gastric Cancer. 16(4):488-97, 2013
  1. D’Onofrio M, Barbi E, Dietrich CF, Kitano M, Numata K, Sofuni A, Principe F, Gallotti A, Zamboni GA, Mucell RP: Pancreatic multicenter ultrasound study (PAMUS). Eur J Radiol 81: 630-638, 2012
  2. Enomoto S, Watanabe M, Mukoubayashi C, Ohata H, Magari H, Inoue I, Maekita T, Iguchi M, Yanaoka K, Tamai H, Kato J, Oka M, Ichinose M; Gastric Cancer Risk Diagnosis and Prevention in Subjects with Helicobacter pylori-related Chronic Gastritis. In " Gastritis and Gastric Cancer" (P. Tonio, ed.), Intech Open Access Publisher. 179-196, 2012
  3. Enomoto S, Watanabe M, Yoshida T, Mukoubayashi C, Moribata K, Muraki Y, Shingaki N, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Tamai H, Kato J, Fujishiro M, Oka M, Mohara O, Ichinose M.　 Relationship between vomiting reflex during esophagogastroduodenoscopy and dyspepsia symptoms. Dig Endosc. 24:325-30, 2012.
  4. Fukatsu K, Ueda K, Maeda H, Yamashita Y, Itonaga M, Mori Y, Moribata K, Shingaki N, Deguchi H, Enomoto S, Inoue I, Maekita T, Iguchi M, Tamai H, Kato J, Ichinose M. A case of chronic pancreatitis in which endoscopic ultrasonography was effective in the diagnosis of a pseudoaneurysm. World J Gastrointest Endosc. 4:335-8, 2012.
  5. Hirakawa T, Kato J, Okumura Y, Hori K, Takahashi S, Suzuki H, Akita M, Higashi R, Saito S, Kaji E, Uraoka T, Hiraoka S, Yamamoto K: Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2 deoxy-D:-glucose positron emission tompgraphy and computed tomography (FDG-PET/CT). J Gastroenterol, 47: 127-35, 2012
  6. Hirakawa T, Kato J: Reply to the letter by A. S. Ravi Kumar et al. regarding "Detectability of colorectal neoplasia with FDG-PET/CT. J Gastroenterol, 47;728-9, 2012
  7. Hiraoka S, Kato J, Suzuki H, Yamamoto K: Readministration of calcineurin inhibitors for ulcerative colitis. Ann Pharmacother 46;1315-21, 2012
  8. Horii J, Kato J, Nagasaka T, Hiraoka S, Sun DS, Watanabe K, Fujita I, Toyokawa T, Tomoda J, Yamamoto K. Development of invasive colon cancer with microsatellite instability in a patient with hyperplastic polyposis syndrome. Jpn J Clin Oncol. 42:451-4, 2012
  9. Itonaga M, Ueda K, Ichinose M. Phlegmonous gastritis caused by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Dig Endosc. 24:488,2012.
  10. Kaji E, Uraoka T, Kato J, Hiraoka S, Suzuki H, Akita M, Saito S, Tanaka T, Ohara N, Yamamoto K. Externalization of saw-tooth architecture in small serrated polyps implies the presence of methylation of IGFBP7. Dig Dis Sci. 57: 1261-70, 2012
  11. Kim JG, Takeshima H, Niwa T, Rehnberg E, Shigematsu Y, Yoda Y, Yamashita S, Kushima R, Maekita T, Ichinose M, Katai H, Park WS, Hong YS, Park CH, Ushijima T; Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. Cancer Lett. 330:33-40, 2013
  12. Kitano M, Kudo M, Yamao K, Takagi T, Sakamoto H, Komaki T, Kamata K, Imai H, Chiba Y, Okada M, Murakami T, Takeyama Y: Characterization of small solid tumors in the pancreas: The value of contrast-enhanced harmonic endoscopic ultrasonography. Am J Gastroenterol 107: 303-310, 2012
  13. Maekita T, Kato J, Nakatani Y, Enomoto S, Kayama T, Tsuji M, Nakaya T, Muraki Y, Deguchi H, Ueda K, Inoue I, Iguchi M, Tamai H, Ichinose M. Usefulness of a continuous suction mouthpiece during percutaneous endoscopic gastrostomy: A single-center, prospective, randomized study. Dig Endosc. 5:508-13, 2013
  14. Matsuda Y, Yamashita S, Lee YC, Niwa T, Yoshida T, Gyobu K, Igaki H, Kushima R, Lee S, Wu MS, Osugi H, Suehiro S, Ushijima T. Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization. Cancer Causes Control. 23(6) : 865-73, 2012.
  15. Moribata K, Kato J and Ichinose M; Microcoil slipping out of the gastric varices. Clin Gastroenterol Hepatol 10; e53, 2012.
  16. Moribata K, Tamai H, Shingaki N, Mori Y, Shiraki T, Enomoto S, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Ichinose M. Ultrasonogram of hepatocellular carcinoma is associated with outcome after radiofrequency ablation. World J Hepatol. 4(12):374-81. 2012
  17. Muraki Y, Enomoto S, Iguchi M, Fujishiro M, Yahagi N, Ichinose M: Management of bleeding and artificial gastric ulcers associated with endoscopic submucosal dissection. World Journal of Gastrointestinal Endoscopy 4: 1-8, 2012
  18. Muraki Y, Enomoto S, Iguchi M, Niwa T, Maekita T, Yoshida T, Moribata K, Shingaki N, Deguchi H, Ueda K, Inoue I, Tamai H, Kato J, Fujishiro M, Ichinose M; Diazepam during endoscopic submucosal dissection of gastric epithelial neoplasias. World Journal of Gastrointestinal Endoscopy 4; 80-86, 2012.
  19. Nanjo S, Asada K, Yamashita S, Nakajima T, Nakazawa K, Maekita T, Ichinose M, Sugiyama T, Ushijima T; Identification of gastric cancer risk markers informative among individuals with past H. pylori infection. Gastric Cancer 15;382-388, 2012.
  20. Niimi K, Fujishiro M, Goto O, Kodashima S, Minatsuki C, Hirayama I, Mochizuki S, Ono S, Yamamichi N, Kakushima N, Ichinose M, Koike K. Prospective single-arm trial of two-week rabeprazole treatment for ulcer healing after gastric endoscopic submucosal dissection. Dig Endosc. 24:110-6, 2012.
  21. Okada M, Ishii K, Numata K, Hyodo T, Kumano S, Kitano M, Kudo M, Murakami T: Can the biliary enhancement of Gd-EOB-DTPA predict the degree of liver function?　 Hepatobiliary Pancreat Dis Int. 11: 307-313, 2012
  22. Sakamoto H, Kimura H, Sekijima M, Matsumoto K, Arao T, Chikugo T, Yamada Y, Kitano M, Ito A, Takeyama Y, Kudo M, Nishio K: Plasma concentrations of angiogenesis-related molecules in patients with pancreatic cancer. Jpn J Clin Oncol 42: 105-112, 2012
  23. Sakamoto H, Kitano M, Kamata K, Miyata T, Kadosaka K, Imai H, Takeyama Y, Kudo M: Transcatheter endoscopy for pancreaticobiliary duct diseases (with videos). Gastrointest Endosc 76: 892-899, 2012
  24. Shigematsu Y, Niwa T, Yamashita S, Taniguchi H, Kushima R, Katai H, Ito S, Tsukamoto T, Ichinose M, Ushijima T. Identification of a DNA methylation marker that detects the presence of lymph node metastases of gastric cancers. Oncol Lett. 40:268-274, 2012.
  25. Tamai H, Moribata K, Mori Y, Shingaki N, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M; Low-dose pegylated interferon-alpha-2a monotherapy in elderly and/or cirrhotic patients infected with hepatitis C virus genotype-2 or genotype-1 low level infection. Hepatol Res 43:702-8, 2013
  26. Watanabe M, Kato J, Yoshimura N, Inoue I, Mukoubayashi C, Yoshida T, Deguchi H, Enomoto S, Ueda K, Maekita T, Iguchi M, Tamai H, Utsunomiya H, Yamamichi N, Fujishiro M, Inada K, Iwane M, Takeshita T, Mohara O, Ushijima T, Ichinose M; Development of gastric cancer in non-atrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis. Int J Cancer 131;2632-2642, 2012.
  27. Yamamichi N, Oka M, Inada K, Konno-Shimizu M, Kageyama-Yahara N, Tamai H, Kato J, Fujishiro M, Kodashima S, Niimi K, Ono S, Tsutsumi Y, Ichinose M, Koike K. Rebamipide induces dendritic cell recruitment to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-exposed rat gastric mucosa based on IL-1β upregulation. Biochem Biophys Res Commun. 424:124-9, 2012.
  1. Enomoto S, Nakazawa K, Ueda K, Mori Y, Maeda Y, Shingaki N, Maekita T, Ota U, Oka M, Ichinose M; Steakhouse syndrome causing large esophageal ulcer and stenosis. World Journal of Gastrointestinal Endoscopy 3; 101-104, 2011
  2. Enomoto S, Oka M, Mukoubayashi C, Watanabe M, Moribata K, Muraki Y, Shingaki N, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Yanaoka K, Tamai H, Ichinose M; Assessment of gastroesophageal reflux disease by serodiagnosis of Helicobacter pylori-related chronic gastritis stage. World Journal of Gastrointestinal Endoscopy 3(4): 71-77, 2011.
  3. Enomoto S, Tamai H, Shingaki N, Mori Y, Moribata K, Shiraki T, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Yanaoka K, Oka M, Ichinose M. Assessment of hepatocellular carcinomas using conventional magnetic resonance imaging correlated with histological differentiation and a serum marker of poor prognosis. Hepatol Int.5(2):730-7, 2011
  4. Hiki　N, Kaminishi　M, Tanabe　S, Fujisaki　J, Yoshino　J, Iguchi　M, Kobayashi　H, Ashida　K, Kawabe　T, Kawano　T, Nomura　S, Yahagi　N, Tajiri　H, Suzuki　H : An open-label, single-arm study assessing the efficacy and safety of L-menthol sprayed onto the gastric mucosa during upper gastrointestinal endoscopy, J of Gastroenterology, 46:873-882, 2011.
  5. Hirakawa T, Kato J, Okumura Y, Hori K, Takahashi S, Suzuki H, Akita M, Higashi R, Saito S, Kaji E, Uraoka T, Hiraoka S, Yamamoto K: Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2 deoxy-D:-glucose positron emission tompgraphy and computed tomography (FDG-PET/CT) J Gastroenterol, 47:127-35, 2012
  6. Inoue I, Mukoubayashi C, Yoshimura N, Niwa T, Deguchi H, Watanabe M, Enomoto S, Maekita T, Ueda K, Iguchi M, Yanaoka K, Tamai H, Arii K, Oka M, Fujishiro M, Takeshita T, Iwane M, Mohara O and Ichinose M; Elevated risk of colorectal adenoma with Helicobacter pylori-related chronic gastritis: a population-based case-control study. Int J Cancer 129; 2704-2711, 2011.
  7. Kaji E, Kato J, Saito S, Harada K, Kuwaki K, Tatsukawa M, Morikawa T, Hiraoka S, Matsushima H, Yamamoto K: Serum folate and homocysteine levels are associated with colon tumorigenesis in end-stage renal disease patients. Nutr Cancer 63: 202-211, 2011
  8. Kaji E, Kato J, Suzuki H, Akita M, Horii J, Saito S, Higashi R, Ishikawa S, Kuriyama M, Hiraoka S, Uraoka T, Yamamoto K: Analysis of K-ras, BRAF, and PIK3CA mutations in laterally-spreading tumors of the colorectum. J Gastroenterol Hepatol. 26: 599-607, 2011
  9. Kaji E, Uraoka T, Kato J, Hiraoka S, Suzuki H, Akita M, Saito S, Tanaka T, Ohara N, Yamamoto K: Externalization of Saw-tooth Architecture in Small Serrated Polyps Implies the Presence of Methylation of IGFBP7. Dig Dis Sci, 57: 1261-70, 2012
  10. Kato J, Kuriyama M, Hiraoka S, Yamamoto K: Is sigmoidoscopy sufficient for evaluating inflammatory status of ulcerative colitis? J Gastroenterol Hepatol. 26: 683-687, 2011
  11. Komaki T, Kitano M, Sakamoto H, Kudo M: Endoscopic ultrasonography-guided biliary drainage: evaluation of a choledochoduodenostomy technique. Pancreatology 11: 47-51, 2011
  12. Kitano M, Sakamoto H, Das K, Komaki T, Kudo M: EUS-guided in vivo microdialysis of the pancreas: a novel technique with potential diagnostic and therapeutic application. Gastrointest Endosc 71: 176-179, 2010
  13. Moribata K, Tamai H, Shingaki N, Mori Y, Enomoto S, Shiraki T, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Yanaoka K, Oka M, Ichinose M. Assessment of malignant potential of small hypervascular hepatocellular carcinoma using B-mode ultrasonography. Hepatol Res. 41(3):233-9, 2011
  14. Moribata T, Kato J, Ichinose M: Microcoil slipping out of the gastric varices. Clin Gastroenterol Hepatol 10, e53, 2012
  15. Moribata T, Kato J, Iimura S, Yoshida S, Shingaki N, Ueda K, Deguchi H, Inoue I, Maekita T, Iguchi M, Tamai H, Ichinose M: Mucosal healing of esophageal involvement of Crohn's disease with granulocyte/monocyte adsorption. J Clin Apher 26:225-7, 2011
  16. Nakaji K, Fujita A , Kumamoto M, Nakae Y, Suzumura S ： Two diospyrobezoars successfully treated by endoscopic fragmentation with the oral intake of Coca-Cola. J. Wakayama Med. Soc 62 36-38 2011
  17. Nakaji K, Fujita A , Suzumura S, Nakae Y, Kumamoto M： Inverted Meckel’s Diverticulum. Internal Medicine.50:935:2011
  18. Nakaji K, Fujita A , Ueda Y, Kumamoto M, Nakae Y, Suzumura S ： Colorectal pneumatosis cystoides intestinalis: A series of nine cases diagnosed during endoscopic examination including a patient undergoing anetholtrithione treatment for Sjogren's syndrome. J. Wakayama Med. Soc 62 31-35, 2011
  19. Nakaji K, Suzumura S , Fujita A , Kumamoto M, Nakae Y , Shiotani A: Effectiveness of Daikenchuto,a Japanese herbal medicine,in accelerating capsule endoscopy transit time- a pilot study. J. Wakayama Med. Soc 62 74-78 2011
  20. Nakata H, Enomoto S, Maekita T, Inoue I, Ueda K, Deguchi H, Shingaki N, Moribata K, Maeda Y, Mori Y, Iguchi M, Tamai H, Yamamichi N, Fujishiro M, Kato J and Ichinose M; Transnasal and standard endoscopies in the screening of neoplasias derived from Helicobacter pylori-related chronic gastritis. World Journal of Gastrointestinal Endoscopy 3; 162-170,2011.
  21. Nakata N, Takayama E, Magari H, Shiraki T, Kondo N, and Ichinose M; Simultaneous detection of T lymphocyte-related antigen (CD4/CD8, CD57, TCR beta) with nuclei by fluorescent-based immunohistochemistry in paraffin- embedded human lymph node, liver cancer and stomach cancer. Acta Cytologica　55:357-363,2011.
  22. Ogata H, Kato J, Hirai F, Hida N, Matsui T, Matsumoto T, Koyanagi K, Hibi T: Double-blind, placebo-controlled trial of oral tacrolimus (FK506) in the management of hospitalized patients with steroid-refractory ulcerative colitis. Inflamm Bowel Dis, Epub, 2011
  23. Saito S, Kato J, Hiraoka S, Horii J, Suzuki H, Higashi R, Kaji E, Kondo Y, Yamamoto K: DNA methylation of colon mucosa un ulcerative colitis patients: Correlation with inflammatory status. Inflamm Bowel Dis, 17;1955-65, 2011
  24. Sakata K, Utsunomiya H, Tokuda A, Ichinose M, and Miyazawa M; Production of new terpenoid from biotransformation of (-)-isolongifolanol by microorganism and suppression of SOS-inducing activity. GBAB: Biocatalysis and Biotrnsformation 2011.
    1. 2. Sakamoto H, Kitano M, Matsui S, Kamata K, Komaki T, Imai H, Dote K, Kudo M: Estimation of malignant potential of GIST by contrast-enhanced harmonic EUS (with video). Gastrointest Endosc, 73: 227-237, 2011
  25. Sakamoto H, Kitano M, Kamata K, Komaki T, Imai H, Chikugo T, Taketyama Y, Kudo M: EUS-guided broad plexus-neurolysis over the superior mesenteric artery using a 25 gauge needle. Am J Gastroenterol 105: 2599-2606, 2010
  26. Sanda M, Tamai H, Deguchi H, Mori Y, Moribata K, Shingaki N, Ueda K, Inoue I, Maekita T, Iguchi M, Yanaoka K, Oka M, Ichinose M. Acalculous cholecystitis in a patient with hepatocellular carcinoma on sorafenib. ISRN Gastroenterol; 201529, 2011
  27. Shigekawa Y, Uchiyama K, Takifuji K, Ueno M, Hama T, Hayami S, Tamai H, Ichinose M, Yamaue H. A laparoscopic splenectomy allows the induction of antiviral therapy for patients with cirrhosis associated with hepatitis C virus. Am Surg. 77(2):174-9, 2011
  28. Shirai K, Inoue I, Kato J, Maeda H, Moribata K, Shingaki N, Ueda K, Deguchi H, Maekita T, Iguchi M, Yanaoka K, Tamai H, Oka M, Kawai M, Yamaue H, Yasuoka H, Nakamura Y, Iso-O N, Ichinose M; A case of a giant glucagonoma with parathyroid hormone-related peptide secretion showing an inconsistent postsurgical endocrine status. Int Med. 50; 1689-1694, 2011.
  29. Shirai K, Tamai H, Shingaki N, Mori Y, Moribata K, Enomoto S, Deguchi H, Ueda K, Maekita T, Inoue I, Iguchi M, Yanaoka K, Oka M, Ichinose M. Clinical features and risk factors of extrahepatic seeding after percutaneous radiofrequency ablation for hepatocellular carcinoma. Hepatol Res. 41(8):738-45, 2011
  30. Shiraki T, Takayama E, Magari H, Nakata T, Maekita T, Enomoto S, Mori Y, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Mizuno-Kamiya M, Yashiro K, Iguchi M, Tamai H, Kameyama Y, Kato J, Kondoh N, Ichinose M. Altered cytokine levels and increased CD4+CD57+ T cells in the peripheral blood of hepatitis C virus-related hepatocellular carcinoma patients. Oncol Rep. 26(1):201-8, 2011
  31. Tamai H, Shingaki N, Shiraki T, Tukuda H, Mori Y, Moribata K, Enomoto S, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Yanaoka K, Oka M, Ichinose M. Prediction of sustained response to low-dose pegylated interferon alpha-2b plus ribavirin in patients with genotype 1b and high hepatitis C virus level using viral reduction within 2?weeks after therapy initiation. Hepatol Res. 41(12):1137-44, 2011
  32. Ueyama T, Ueda K, Kawabe T, Hano T, Tsuruo Y, Nishi T, Ichinose M, Yoshida K; Cardiac gene profiles in an animal model of takotsubo cardiomyopathy. Heart and Vessels 26; 321-337, 2011.
  33. Uraoka T, Higashi R, Kato J, Kaji E, Suzuki H, Ishikawa S, Akita M, Hirakawa T, Saito S, Hori K, Kawahara Y, Mead RJ, Yamamoto K: Colorectal endoscopic submucosal dissection for elderly patients at least 80 years of age. Surg Endosc 25;3000-3007, 2011
  34. Uraoka T, Kawahara Y, Ohara N, Kato J, Hori K, Okada H, Yamamoto K:Carbon dioxide submucosal injection cushion: an innovative technique in endoscopic submucosal dissection. Dig Endosc 23: 5-9, 2011
  35. Xia Y, Kitano M, Kudo M, Imai H, Kamata K, Sakamoto H, Komaki T: Characterization of intra-abdominal lesions of undetermined origin by contrast-enhanced harmonic EUS (with videos). Gastrointest Endosc 72: 637-642, 2010
  36. Yamamichi N, Shimamoto T, Minatsuki C, Yoshida Y, Fujishiro M, Kodashima S, Kato J, Goto O, Ono S, Niimi K, Takahashi Y, Konno-Shimizu M, Ichinose M, Koike K: Postprandial fullness correlates with rapid inflow of gastric content into duodenum but not with chronic gastritis. BMC Gastroenterology 11: 140, 2011
  37. Yoshida H, Shiratori Y, Kudo M, Shiina S, Mizuta T, Kojiro M, Yamamoto K, Koike Y, Saito K, Koyanagi N, Kawabe T, Kawazoe S, Kobashi H, Kasugai H, Osaki Y, Araki Y, Izumi N, Oka H, Tsuji K, Toyota J, Seki T, Osawa T, Masaki N, Ichinose M, Seike M, Ishikawa A, Ueno Y, Tagawa K, Kuromatsu R, Sakisaka S, Ikeda H, Kuroda H, Kokuryu H, Yamashita T, Sakaida I, Katamoto T, Kikuchi K, Nomoto M, Omata M; Effect of vitamin K2 on the recurrence of hepatocellular carcinoma: A randomized, placebo-controlled, double-blind phase II/III study. Hepatology 54:532-540, 2011.
  38. Yoshida T, Yamashita S, Takamura-Enya T, Niwa T, Ando T, Enomoto S, Maekita T, Nakazawa K, Tatematsu M, Ichinose M, Ushijima T; Alu and Satalpha hypomethylation in Helicobacter pylori-infected gastric mucosae. Int J Cancer 128; 33 – 39, 2011.

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