1. カルシウム制御タンパク質の各種疾患（循環器?神経?代謝疾患、がん）に対する病態的意義の解明と薬物治療
2. ヒト心臓突然死の原因となる不整脈のメカニズム解明とテーラーメイド医療
3. 成体と子どもの心機能調節機構の相違と治療戦略
4. イオン動態?力学刺激を介した硬組織疾患メカニズムの解明と薬物探索
5. イオンチャネル?受容体の構造―活性相関と薬物による標的分子の機能制御機構

2024年

• Matsumura S#, Yasuda J#, Notomi T, Suzuki Y, Chen IS, Murakami D, Hotomi M, Nakamura TY*.
  Direct toxicity of cigarette smoke extract on cardiac function mediated by mitochondrial dysfunction in Sprague-Dawley rat ventricular myocytes and human induced pluripotent stem cell-derived cardiomyocytes.
  PLoS One, 19(1): e0295737, 2024
• Chen IS*, Yasuda J, Notomi T, Nakamura TY*.
  Licorice metabolite 18β-glycyrrhetinic acid activates G protein-gated inwardly rectifying K+ channels.
  Br J Pharmacol , 181(3):447-463, 2024.

• Liu C, Chen IS, Tateyama M, Kubo Y.
  Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist.
  J Biol Chem , 300(5):107219, 2024.

2023年

• Gando I, Becerra Flores M, Chen IS, Yang HQ, Nakamura TY, Cardozo TJ, Coetzee WA.
  CL-705G: a novel chemical Kir6.2-specific KATP channel opener
  Front Pharmacol.20;14:1197257. 2023.

• Mao D, Inoue H, Notomi T*, Goda S*.
  P38α contributes to TNF-α-induced IL-8 production in human gingival cells.
  Biofactors, 49(6):1223-1232, 2023.

2022年

• Chen IS*, Eldstrom J, Fedida D, Kubo Y.
  A novel ion conducting route besides the central pore in an inherited mutant of G‐protein‐gated inwardly rectifying K+ channel.
  J Physiol, 600(3):603-622, 2022.

2021年

• Notomi T*, Kobayashi R, Otsuka M, Kise C, Momota Y, Ezura Y, Kawazoe T.
  Light-induced Membrane Hyperpolarization Promotes Osteoblast Differentiation in MC3T3 Osteoblast-like Cells.
  J Hard Tissue Biol, 30: 4: 347-354, 2021
• Notomi T*, Kise C, Kobayashi R, Otsuka M, Momota Y, Ezura Y, Kawazoe T.
  TPC1 and TPC2 Promote Osteoclastogenesis.
  J Hard Tissue Biol, 30: 4: 333-338, 2021
• Notomi T*, Otsuka M, Kise C, Kobayashi R, Momota Y and Kawazoe T.
  Delivery of plasmid DNA into pre-osteoclast-like and mature osteoclast-like cells using cationic peptides.
  J Osaka Dent Univ, 55: 2: 239-243, 2021
• 中村(西谷)友重*
  小児特有の心筋細胞内Ca2+シグナル調節機構とその治療標的としての可能性
  日本薬理学会誌, 2021: 156(6);346-350
• 西谷(中村)友重*
  興奮性細胞における新規Ca2+シグナル制御因子NCS-1の多彩な生理機能と各種疾患との関連
  和歌山医学, 2021;72(4);192-197
• Kiguchi N*, Fukazawa Y, Saika A, Uta D, Saika F, Nakamura TY, Ko MC, Kishioka S.
  Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice.
  Pharmacology research & perspectives, 2021; 9; e00790
• Saika F, Matsuzaki S, Kishioka S, Kiguchi N.
  Chemogenetic Activation of CX3CR1-Expressing Spinal Microglia Using Gq-DREADD Elicits Mechanical Allodynia in Male Mice
  Cells, 2021; 10; 874
• Matsuki Y, Yanagawa T, Sumiyoshi H, Yasuda J, Nakao S, Goto M, Shibata-Seki T, Akaike T, Inagaki Y.
  Modification of exosomes with carbonate apatite and a glycan polymer improves transduction efficiency and target cell selectivity.
  Bioche Biophys Res Commun. 2021; 583 93-99
• Sumiyoshi H, Okamura Y, Kawaguchi T A, Kubota T, Endo H, Yanagawa T, Yasuda J, Matsuki Y, Nakao S, Inagaki Y.
  External administration of moon jellyfish collagen solution accelerates physiological wound healing and improves delayed wound closure in diabetic model mice.
  Regenerative Therapy, 2021; 18 223-230

2020年

• Kiguchi N*, Ding H, Ko MC.
  Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse.
  J Neurosci Res. 2020 Apr 7. [Epub ahead of print] Review. PMID: 32255240
• Kiguchi N*,#, Uta D#, Ding H, Uchida H, Saika F, Matsuzaki S, Fukazawa Y, Abe M, Sakimura K, Ko MC, Kishioka S.
  Neuropharmacology. 2020 Mar 3;170:108025. PMID: 32142790
• Kobayashi D*, Kiguchi N, Saika F, Kishioka S, Matsuzaki S*.
  Insufficient efferocytosis by M2-like macrophages as a possible mechanism of neuropathic pain induced by nerve injury.
  Biochem Biophys Res Commun. 2020 Feb 19. [Epub ahead of print] PMID: 32087968
• 陳以珊*, 久保義弘.
  GIRKチャンネルの、小分子による新規機能調節機構.
  心電図 2020; 40(2);107-113.

2019年

• Nakamura TY*, Nakao S, Wakabayashi S.
  Emerging Roles of neuronal Ca2+ Sensor-1 in Cardiac and neuronal Tissues：A Mini Review
  Front. Mol. Neurosci. 2019 12:56.
• Kiguchi N, Ko MC*.
  Effects of NOP-Related Ligands in Nonhuman Primates.
  Handb Exp Pharmacol. 2019;254:323-343. PMID: 30879202
• Kiguchi N#, Ding H#, Cami-Kobeci G, Sukhtankar DD, Czoty PW, DeLoid HB, Hsu FC, Toll L, Husbands SM*, Ko MC*.
  BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.
  Br J Anaesth. 2019 Jun;122(6):e146-e156. PMID: 30916003
• Saika F, Kiguchi N*, Matsuzaki S, Kobayashi D, Kishioka S.
  Inflammatory macrophages in the sciatic nerves facilitate neuropathic pain associated with type 2 diabetes mellitus.
  J Pharmacol Exp Ther. 2019 Mar;368(3):535-544. PMID: 30602591
• Chen IS*, Liu C, Tateyama M, Karbat I, Uesugi M, Reuveny E, Kubo Y.
  Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels.
  Br J Pharmacol. 2019; 176(17):3161-3179.
• Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack J, Kurachi Y.
  Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations.
  J Gen Physiol. 2019; 151(2):214-230.
• Ishii J, Suzuki A, Kimura T, Tateyama M, Tanaka T, Yazawa T, Arimasu Y, Chen IS, Aoyama K, Kubo Y, Saitoh S, Mizuno H, Kamma H.
  Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A7.
  Commun Biol. 2019; 2:270.
• Yasuda J, Okada M, Yamawaki H.
  Protective effects of T3 peptide, an active fragment of tumstatin, against ischemia/reperfusion injury in rat heart.
  J. Pharmacol. Sci. 139: 193-200, 2019.
• Notomi T*, Hiyama A, Nozaki T.
  Establishment of RANKL-highly sensitive RAW264 subclones in accordance with high expression of TPC2.
  J Transl Sci, 6, 2019. doi: 10.15761/JTS.1000357 (4 pages).
• Notomi T*, Hiyama A, Nozaki T.
  Role of zinc and zinc-modulated ion channels, ORAI1 and HCN in osteoclasts.
  J Transl Sci, 6, 2019. doi: 10.15761/JTS.1000359 (4 pages)
• Inubushi M, Notomi T*, Nozaki T. Retinoic acid promotes migration of MC3T3-E1 osteoblast-like cells via RARα signaling-mediated upregulation of profilin-1 expression.
  J Osaka Dent Univ, 53: 2: 149-156, 2019.
• Notomi T*, Inubushi M, Nozaki T.
  Synaptotagmin VII RANKL-lysosomal vesicle fusion to the cell membrane in osteoblast-like cells.
  J Osaka Dent Univ, 53: 2: 141-147, 2019.

2018年

• Kiguchi N*, Matsuzaki S, Saika F, Kobayashi D, Kishioka S.
  Epigenetic Regulation of Peripheral Macrophages in Neuropathic Pain.
  In: Epigenetics of Chronic Pain. Translational Epigenetics, 2018; 7: p49-68.
• Saika F, Matsuzaki S, Kobayashi D, Kiguchi N*, Kishioka S.
  Chemokine CXCL1 is responsible for cocaine-induced reward in mice.
  Neuropsychopharmacol Rep. 2018 Sep;38(3):145-148. PMID: 30175527.
• Ding H#, Kiguchi N#, Yasuda D, Daga PR, Polgar WE, Lu JJ, Czoty PW, Kishioka S, Zaveri NT*, Ko MC*.
  A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.
  Sci Transl Med. 2018 Aug 29;10(456). pii: eaar3483. PMID: 30158150.
• Ding H#, Kiguchi N*,#, Kishioka S, Ma T, Peters CM, Ko MC. Differential mRNAexpression of neuroinflammatory modulators in the spinal cord and thalamus oftype 2 diabetic monkeys.
  J Diabetes. 2018 Nov;10(11):886-895. PMID: 29749036.
• Kiguchi N*, Kobayashi D, Saika F, Matsuzaki S, Kishioka S. Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury.
  J Neuroinflammation. 2018 Mar 27;15(1):96. PMID: 29587798.
• Saika F, Kiguchi N*, Wakida N, Kobayashi D, Fukazawa Y, Matsuzaki S, Kishioka S.
  Upregulation of CCL7 and CCL2 in reward system mediated through dopamine D1 receptor signaling underlies methamphetamine-induced place preference in mice.
  Neurosci Lett. 2018 Feb 5;665:33-37. PMID: 29174638.
• Chen IS* and Kubo Y.
  Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.
  J Physiol. 2018; 596(10):1833-1845.

2017年

• Nakamura TY*, Nakao S, Nakajo Y, Takahashi JC, Wakabayashi S, Yanamoto H:
  Possible Signaling Pathways Mediating Neuronal Calcium Sensor-1-Dependent Spatial Learning and Memory in Mice. PLoS ONE, 2017 12(1) e0170829.
• Kiguchi N*, Kobayashi D, Saika F, Matsuzaki S, Kishioka S.
  Pharmacological Regulation of Neuropathic Pain Driven by Inflammatory Macrophages.
  Int J Mol Sci. 2017 Nov 1;18(11). pii: E2296. Review. PMID: 29104252.
• Kiguchi N*, Sakaguchi H, Kadowaki Y, Saika F, Fukazawa Y, Matsuzaki S, Kishioka S.
  Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation.
  J Pharmacol Sci. 2017 Jan;133(1):53-56. PMID: 28057412.
• Kiguchi N, Ding H, Peters CM, Kock ND, Kishioka S, Cline JM, Wagner JD, Ko MC*.
  Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys.
  Biochim Biophys Acta. 2017 Jan;1863(1):274-283. PMID: 27751964.
• Chen IS*, Tateyama M, Fukata Y, Uesugi M, Kubo Y.
  Ivermectin activates GIRK channels in a PIP2-dependent, Gβγ-independent manner and an amino acid residue at the slide helix governs the activation.
  J Physiol. 2017; 595(17):5895-5912.
• Chen IS, Furutani K, Kurachi Y.
  Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity.
  Sci Rep. 2017; 7(1):6110.
• Tsukamoto H, Chen IS, Kubo Y, Furutani Y.
  A ciliary opsin in the brain of a marine annelid zooplankton is ultraviolet-sensitive, and the sensitivity is tuned by a single amino acid residue.
  J Bio Chem. 2017; 292(31):12971-12980.
• Yasuda J, Fukui K, Okada M, Yamawaki H.
  T3 peptide, a fragment of tumstatin, stimulates proliferation and migration of cardiac fibroblasts through activation of Akt signaling pathway.
  Naunyn-Schmiedeberg’s Arch. Pharmacol. 390: 1135-1144, 2017.
• Yasuda J, Okada M, Yamawaki H.
  T3 peptide, an active fragment of tumstatin, inhibits H2O2-induced apoptosis in H9c2 cardiomyoblasts.
  Eur. J. Pharmacol. 807: 64-70, 2017.
• Okada M, Imoto K, Sugiyama A, Yasuda J, Yamawaki H.
  New Insights into the Role of Basement Membrane-Derived Matricryptins in the Heart.Biol. Pharm. Bull. 40: 2050-2060, 2017.
• Notomi T*, Kuno M, Hiyama A, Nozaki T, Ohura K, Ezura Y, Noda M.
  Role of lysosomal channel protein TPC2 in osteoclast differentiation and bone remodeling under normal and low-magnesium conditions.
  J Biol Chem, 292: 12: 20998-21010, 2017.

2016年

• Nakamura TY*, Nakao S, Wakabayashi S.
  Neuronal Ca2+ sensor-1 contributes to stress tolerance in cardiomyocytes via activation of mitochondrial detoxification pathways.
  J. Mol Cell Cardiol. 2016 99:23-34.
• Ding H, Czoty PW, Kiguchi N, Cami-Kobeci G, Sukhtankar DD, Nader MA, Husbands SM, Ko MC*.
  A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates.
  Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5511-8. PMID: 27573832.
• Kiguchi N, Ding H, Ko MC*.
  Central N/OFQ-NOP Receptor System in Pain Modulation.
  Adv Pharmacol. 2016;75:217-43. Review. PMID: 26920014.
• Kiguchi N, Sukhtankar DD, Ding H, Tanaka K, Kishioka S, Peters CM, Ko MC*.
  Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice.
  J Pharmacol Exp Ther. 2016 Mar;356(3):596-603. PMID: 26669425.
• Nakamoto T, Izu Y, Kawasaki M, Notomi T, Hayata T, Noda M, Ezura Y.
  Mice deficient in CIZ/NMP4 develop an attenuated from of K/BxN-serum induced arthritis.
  J Cell Biochem, 117: 4: 970-7, 2016.

2015年

• Kobayashi S, Nakamura TY, Wakabayashi S*.
  Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation.
  J. Mol. Cell. Cardiol., 2015, 84:133-42.
• Nakao S, Wakabayashi S, Nakamura, TY*.
  Stimulus-dependent regulation of nuclear Ca2+ signaling in cardiomyocytes: a role of neuronal calcium sensor-1.
  PLoS ONE, 2015 10(4):e0125050.
• Kiguchi N, Saika F, Kobayashi Y, Ko MC, Kishioka S*.
  TC-2559, an α4β2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1β through STAT3 inhibition in cultured murine macrophages.
  J Pharmacol Sci. 2015 Jun;128(2):83-6. PMID: 26012743.
• Kobayashi Y, Kiguchi N, Fukazawa Y, Saika F, Maeda T, Kishioka S*.
  Macrophage-T cell interactions mediate neuropathic pain through the glucocorticoid-induced tumor necrosis factor ligand system.
  J Biol Chem. 2015 May 15;290(20):12603-13. PMID: 25787078.
• Kiguchi N, Kobayashi Y, Saika F, Sakaguchi H, Maeda T, Kishioka S*.
  Peripheral interleukin-4 ameliorates inflammatory macrophage-dependent neuropathic pain.
  Pain. 2015 Apr;156(4):684-93. PMID: 25630024.
• Saika F, Kiguchi N, Kobayashi Y, Kishioka S*.
  Peripheral alpha4beta2 nicotinic acetylcholine receptor signalling attenuates tactile allodynia and thermal hyperalgesia after nerve injury in mice.
  Acta Physiol (Oxf). 2015 Feb;213(2):462-71. PMID: 25491757.
• Yasuda J, Okada M, Yamawaki H.
  Endostatin inhibits T-type Ca2+ channel current in guinea pig ventricular myocyte.
  J. Vet. Med. Sci. 77: 1289-1291, 2015.
• Yasuda J, Takada L, Kajiwara Y, Okada M, Yamawaki H.
  Endostatin inhibits bradykinin-induced cardiac contraction.
  J. Vet. Med. Sci. 77: 1391-1395, 2015.
• Notomi T*, Kuno M, Hiyama A, Ezura Y, Honma M, Ishizuka T, Ohura K, Yawo H, Noda M.
  Membrane depolarization regulates intracellular RANKL transport in non-excitable osteoblasts.
  Bone, 81: 1: 306-14, 2015.
• Notomi T*, Kuno M, Hiyama A, Ohura K, Noda M, Skerry TM.
  Zinc-induced effects on osteoclastogenesis involves activation of hyperpolarization-activated cyclic nucleotide modulated channels via changes in membrane potential.
  J Bone Miner Res, 30: 9: 1618-26, 2015.
• Aryal S, Miyai K, Izu Y, Hayata T, Notomi T, Noda M, Ezura Y.
  Nck influences preosteoblastic/osteoblastic migration and bone mass.
  Proc Natl Acad Sci USA, 112: 50: 15432-7, 2015.
• Kawasaki M, Ezura Y, Hayata T, Notomi T, Izu Y, Noda M.
  TGF-Beta Suppresses Ift88 Expression in Chondrocytic ATDC5 cells.
  J Cell Physiol, 230: 11: 2788-95, 2015.
• Yamada T, Ezura Y, Hayata T, Moriya S, Shirakawa J, Notomi T, Aryal S, Kawasaki M, Izu Y, Harada K, Noda M.
  β2 Adrenergic receptor activation suppresses BMP-induced alkaline phosphatase expression in osteoblast-like MC3T3E1 cells.
  J Cell Biochem, 116: 6: 1144-52, 2015.
• Moriya S, Hayata T, Notomi T, Aryal S, Nakamoto T, Izu Y, Kawasaki M, Yamada T, Shirakawa J, Kaneko K, Ezura Y, Noda M.
  PTH regulates β2-adrenergic receptor expression in osteoblast-like MC3T3-E1 cells.
  J Cell Biochem, 116: 1: 142-8, 2015.
• 雑賀史浩, 木口倫一, 岸岡史郎.
  The role of CC-chemokine ligand 2 in the development of psychic dependence on methamphetamine.
  日本アルコール薬物医学会雑誌 2015; 50(5): 189-195.
• 小林悠佳, 木口倫一, 雑賀史浩, 岸岡史郎.
  Exploration of novel therapeutic targets for neuropathic pain based on the regulation of immune cells.
  日本神経精神薬理学雑誌 2015; 35(3): 65-72.
• 小林悠佳, 岸岡史郎.
  新規疼痛制御分子としてのマクロファージ由来マトリックスメタロプロテアーゼ12 の可能性.
  PAIN RESEARCH. 2015; 30(1): 37-45.

2014年

• Kuramoto K, Sakai F, Yoshinori N, Nakamura TY, Wakabayashi S, Kojidani T, Haraguchi T, Hirose F, Osumi T*.
  Deficiency of a lipid droplet protein, perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunction.
  Mol. Cell. Biol., 2014 34:2721-31.
• Shimada-Shimizu N, Hisamitsu T, Nakamura TY, Hirayama N, Wakabayashi S*.
  Na+/H+ exchanger 1 is regulated via its lipid-interacting domain, which functions as a molecular switch: a pharmacological approach using indolocarbazole compounds.
  Mol. Pharmacol., 2014, 85:18-28.
• Wakida N, Kiguchi N*, Saika F, Nishiue H, Kobayashi Y, Kishioka S.
  CC-chemokine ligand 2 facilitates conditioned place preference to methamphetamine through the activation of dopamine systems.
  J Pharmacol Sci. 2014;125(1):68-73. PMID: 24748435.
• Ueno K, Kiguchi N, Kobayashi Y, Saika F, Wakida N, Yamamoto C, Maeda T, Ozaki M, Kishioka S*.
  Possible involvement of endogenous opioid system located downstream of α7 nicotinic acetylcholine receptor in mice with physical dependence on nicotine.
  J Pharmacol Sci. 2014;124(1):47-53. PMID: 24366190.
• Kiguchi N, Kobayashi Y, Kadowaki Y, Fukazawa Y, Saika F, Kishioka S*.
  Vascular endothelial growth factor signaling in injured nerves underlies peripheral sensitization in neuropathic pain.
  J Neurochem. 2014 Apr;129(1):169-78. PMID: 24304382.
• Kiguchi N, Saika F, Kobayashi Y, Kishioka S*.
  Epigenetic regulation of CC-chemokine ligand 2 in nonresolving inflammation.
  Biomol Concepts. 2014 Aug;5(4):265-73. Review. PMID: 25372758.
• Kishioka S*, Kiguchi N, Kobayashi Y, Saika F.
  Nicotine effects and the endogenous opioid system.
  J Pharmacol Sci. 2014;125(2):117-24. Review. PMID: 24882143.
• Chen IS, Furutani K, Inanobe A, Kurachi Y.
  RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents.
  J Physiol. 2014; 592(6): 1237-1248.
• Notomi T*, Karasaki I, Okazaki Y, Okimoto N, Kato Y, Ohura K, Noda M, Nakamura T, Suzuki M.
  Insulinogenic sucrose + amino acid mixture ingestion immediately after resistance exercise has an anabolic effect on bone compared with non-insulinogenic fructose + amino acid mixture in growing rats.
  Bone, 65: 1: 42-48, 2014.
• Shirakawa J, Ezura Y, Moriya S, Kawasaki M, Yamada T, Notomi T, Nakamoto T, Hayata T, Miyawaki A, Omura K, Noda M.
  Migration linked to FUCCI-indicated cell cycle is controlled by PTH and mechanical stress.
  J Cell Physiol, 229: 10: 1353-8, 2014.
• Watanabe C, Morita M, Ezura Y, Nakamoto T, Hayata T, Kikuguchi C, Xue L, Kobayashi Y, Takahashi N, Notomi T, Moriyama K, Tadashi Yamamoto, Noda M.
  Stability of mRNA influences osteoporotic bone mass via Cnot3.
  Proc Natl Acad Sci USA, 111: 7: 2692-7, 2014.
• 西谷（中村）友重*、若林繁夫
  幼少期の心機能を制御する新しいCa2+調節タンパク質の発見とその分子機構
  日本小児循環器学会雑誌, 2014, 30(3):224-231.
• 木口倫一, 岸岡史郎.
  傷害末梢神経におけるヒストン修飾は神経障害性疼痛を調節する.
  PAIN RESEARCH. 2014; 29(1): 9-16.
• 岸岡史郎, 木口倫一, 小林悠佳, 雑賀史浩, 山本千鶴子.
  The development of physical dependence on nicotine and endogenous opioid system--participation of alpha7 nicotinic acetylcholine receptor.
  日本アルコール薬物医学会雑誌 2014; 49(5): 227-237.
• 納富拓也（宮村実晴編）、ニュー運動生理学（運動と骨格：骨形態）、真興交易（株）医書出版部、　262-270頁、2014

2013年

• Shimada-Shimizu N, Hisamitsu T, Nakamura TY, Wakabayashi S*.
  Evidence that Na+ /H+ exchanger 1 is an ATP-binding protein.
  FEBS J. 2013, 280:1430-42.
• Kiguchi N, Kobayashi Y, Saika F, Kishioka S*.
  Epigenetic upregulation of CCL2 and CCL3 via histone modifications in infiltrating macrophages after peripheral nerve injury.
  Cytokine. 2013 Dec;64(3):666-72. PMID: 24135048.
• Kishioka S*, Kiguchi N, Kobayashi Y, Yamamoto C, Saika F, Wakida N, Ko MC, Woods JH.
  Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice.
  Neurosci Lett. 2013 Sep 27;552:98-102. PMID: 23933210.
• Maeda T*, Ozaki M, Kobayashi Y, Kiguchi N, Kishioka S.
  HMGB1 as a potential therapeutic target for neuropathic pain.
  J Pharmacol Sci. 2013;123(4):301-5. Review. PMID: 24285082.
• Wakabayashi S*, Hisamitsu T, Nakamura TY.　
  Regulation of the cardiac Na+/H+ exchanger in health and disease.
  J. Mol. Cell. Cardiol. 2013, 61:68-76
• Suzuki T, Notomi T*, Miyajima D, Mizoguchi F, Hayata T, Nakamoto T, Hanyu R, Kamolratanakul P, Mizuno A, Makoto Suzuki, Ezura Y, Izumi Y, Noda M.
  Osteoblastic differentiation enhances expression of TRPV4 that is required for calcium oscillation induced by mechanical force.
  Bone, 54: 1: 172-8, 2013.
• Aryal S, Miyai K, Ezura Y, Hayata T, Notomi T, Nakamoto T, Pawson T, Noda M.
  Nck1 deficiency accelerates unloading-induced bone loss.
  J Cell Physiol, 228: 7: 1397-1403, 2013.

2012年

• Kuramoto K, Okamura T, Yamaguchi T, Nakamura TY, Wakabayashi S, Morinaga H,
  Nomura M, Yanase T, Otsu K, Usuda N, Matsumura S, Inoue K, Fushiki T, Kojima Y,
  Hashimoto T, Sakai F, Hirose F, Osumi T*.
  Perilipin 5, a lipid droplet-binding protein, protects the heart from oxidative burden by sequestering fatty acid from excessive oxidation.
  J. Biol. Chem. 2012, 287:23852-63.　
• Hisamitsu T, Nakamura TY, Wakabayashi S*.
  Na+/H+ exchanger 1 directly binds to calcineurin a and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy.
  Mol. Cell. Biol. 2012, 32:3265-80.　
• Kiguchi N, Kobayashi Y, Maeda T, Tominaga S, Nakamura J, Fukazawa Y, Ozaki M, Kishioka S*.
  Activation of nicotinic acetylcholine receptors on bone marrow-derived cells relieves neuropathic pain accompanied by peripheral neuroinflammation.
  Neurochem Int. 2012 Dec;61(7):1212-9. PMID: 22989685.
• Saika F, Kiguchi N*, Kobayashi Y, Fukazawa Y, Kishioka S.
  CC-chemokine ligand 4/macrophage inflammatory protein-1β participates in the induction of neuropathic pain after peripheral nerve injury.
  Eur J Pain. 2012 Oct;16(9):1271-80. PMID: 22528550.
• Kobayashi Y, Kiguchi N, Maeda T, Ozaki M, Kishioka S*. The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice.
  Biochem Biophys Res Commun. 2012 May 4;421(2):318-22. PMID: 22503971.
• Ueno K, Maeda T, Kiguchi N, Kobayashi Y, Ozaki M, Kishioka S*.
  Availability of serum corticosterone level for quantitative evaluation of morphine withdrawal in mice.
  Drug Discov Ther. 2011 Apr;5(2):71-5. PMID: 22466143.
• Iwai S, Kiguchi N*, Kobayashi Y, Fukazawa Y, Saika F, Ueno K, Yamamoto C, Kishioka S.
  Inhibition of morphine tolerance is mediated by painful stimuli via central mechanisms.
  Drug Discov Ther. 2012 Feb;6(1):31-7. PMID: 22460426.
• Kiguchi N, Kobayashi Y, Maeda T, Fukazawa Y, Tohya K, Kimura M, Kishioka S*.
  Epigenetic augmentation of the macrophage inflammatory protein 2/C-X-C chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain.
  J Pharmacol Exp Ther. 2012 Mar;340(3):577-87. PMID: 22135382.
• Kiguchi N, Kobayashi Y, Kishioka S*.
  Chemokines and cytokines in neuroinflammation leading to neuropathic pain.
  Curr Opin Pharmacol. 2012 Feb;12(1):55-61. Review. PMID: 22019566.
• Nakamura TY*, Wakabayashi S.
  Role of neuronal calcium sensor-1 in the cardiovascular system.
  Trends Cardiovasc. Med 2012., 22:12-17.
• Nakamura TY*, Wakabayashi S.
  Diverse functions of neuronal calcium sensor-1 (NCS-1) in excitable cells.
  Trends in Cell & Molecular Biology 2012, 7:99-110.
• Notomi T*, Ezura Y, Noda M.
  Identification of two pore channel 2 as a novel regulator of osteoclastogenesis.
  J Biol Chem, 287: 42: 35057-64, 2012.
• Miyajima D, Hayata T, Suzuki T, Hemmi H, Ezura Y, Nakamoto T, Notomi T, Amagasa T, Böttcher RT, Costell M, Fässler R, Noda M.
  Profilin1 regulates sternum development and endochondral bone formation.
  J Biol Chem, 287: 40: 33545-53, 2012.
• Hanyu R, Wehbi VL, Hayata T, Moriya S, Feinsteind TN, Ezura Y, Nagao M, Saita Y, Hemmi H, Notomi T, Nakamoto T, Schipani E, Takeda S, Kaneko K, Kurosawa H, Karsenty G, Kronenberg HM, Vilardaga JP, Noda M.
  Anabolic action of parathyroid hormone regulated by the beta2-adrenergic receptor.
  Proc Natl Acad Sci USA,109: 19: 7433-8, 2012.
• Sakuma T, Nakamoto T, Hemmi H, Kitazawa S, Kitazawa R, Notomi T, Hayata T, Ezura Y, Amagasa T, Noda M.
  CIZ/NMP4 is expressed in B16 melanoma and forms a positive feedback loop with RANKL to promote migration of the melanoma cells.
  J Cell Physiol, 227: 7: 2807-12, 2012.
• Yumoto K, Nifuji A, Rittling S, Tsuchiya Y, Kon S, Uede T, Denhardt DT, Hemmi H, Notomi T, Hayata T, Ezura Y, Nakamoto T, Noda M.
  Osteopontin deficiency suppresses tumor necrosis factor-α–induced apoptosis in chondrocytes.
  Cartilage, 3: 1: 79-85, 2012.
• 木口倫一.
  炎症性ケモカインによる慢性神経炎症を介した神経障害性疼痛形成の分子基盤
  和歌山医学. 2012; 63(3): 98-103. 和歌山医学会.

2011年

• Nakamura TY* , Jeromin A, Mikoshiba K, Wakabayashi S.
  Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals.
  Circ. Res. 2011, 109:512-23.
• Yamamoto A, Kiguchi N*, Kobayashi Y, Maeda T, Ueno K, Yamamoto C, Kishioka S.
  Pharmacological relationship between nicotinic and opioid systems in analgesia and corticosterone elevation.
  Life Sci. 2011 Dec 19;89(25-26):956-61. PMID: 22036617.
• Chen IS, Dai ZK, Welsh DG, Chen IJ, Wu BN.
  Protein kinases modulate store- operated channels in pulmonary artery smooth muscle cells.
  J Biomed Sci. 2011; 18(2):1-12.
• Nagao M, Feinstein TN, Ezura Y, Hayata T, Notomi T, Saita Y, Hanyu R, Hemmi H, Izu Y, Takeda S, Wang K, Rittling S, Nakamoto T, Kaneko K, Kurosawa H, Karsenty G, Denhardt DT, Vilardaga JP, Noda M.
  Sympathetic control of bone mass regulated by osteopontin.
  Proc Natl Acad Sci USA, 108: 43: 17767-72, 2011.
• Kondo H, Ezura Y, Nakamoto T, Hayata T, Notomi T, Sorimachi H, Takeda S, Noda M.
  MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss.
  J Cell Biochem, 112: 12: 3525-30, 2011.
• Hanyu R, Hayata T, Nagao M, Saita Y, Hemmi H, Notomi T, Nakamoto T, Schipani E, Kronenberg H, Kaneko K, Kurosawa H, Ezura Y, Noda M.
  Per-1 is a specific clock gene regulated by parathyroid hormone (PTH) signaling in osteoblasts and is functional for the transcriptional events induced by PTH.
  J Cell Biochem, 112: 2: 433-8, 2011.
• Kamolratanakul P, Hayata T, Ezura Y, Kawamata A, Hayashi C, Yamamoto Y, Hemmi H, Nagao M, Hanyu R, Notomi T, Nakamoto T, Amagasa T, Akiyoshi K, Noda M.
  Nanogel-based scaffold delivery of prostaglandin E(2) receptor-specific agonist in combination with a low dose of growth factor heals critical-size bone defects in mice.
  Arthritis Rheum, 63: 4: 1021-33, 2011.
• Morishita M, Ono N, Miyai K, Nakagawa T, Hanyu R, Nagao M, Kamolratanakul P, Notomi T, Rittling S, Denhardt DT, Kronenberg HM, Ezura Y, Hayata T, Nakamoto T, Noda M.
  Osteopontin deficiency enhances parathyroid hormone/parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology.
  Tissue Cell, 43: 3: 196-200, 2011.
• Nagao M, Saita Y, Hanyu R, Hemmi H, Notomi T, Hayata T, Nakamoto T, Nakashima K, Kaneko K, Kurosawa H, Ishii S, Ezura Y, Noda M.
  Schnurri-2 deficiency counteracts against bone loss induced by ovariectomy.
  J Cell Physiol, 226: 3: 573-8, 2011.
• 木口倫一, 岸岡史郎.
  神経炎症が関与する末梢神経障害性疼痛のメカニズム.
  ペインクリニック. 2011; 32 (10): pp1499-1509. 真興交易（株）.